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2016 ; 11
(6
): 2177-2184
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Clinical effect of ticagrelor administered in acute coronary syndrome patients
following percutaneous coronary intervention
#MMPMID27284299
Lu Y
; Li Y
; Yao R
; Li Y
; Li L
; Zhao L
; Zhang Y
Exp Ther Med
2016[Jun]; 11
(6
): 2177-2184
PMID27284299
show ga
The aim of the present study was to retrospectively analyze the clinical effect
and safety of ticagrelor administration in acute coronary syndrome (ACS) patients
following percutaneous coronary intervention (PCI). In total, 203 patients were
enrolled, who were confirmed with ACS between March 2013 and May 2013, and had
successfully undergone PCI. The patients were randomly divided into two groups,
including the clopidogrel (group A, n=108) and ticagrelor groups (group B, n=95).
Patients in group A were treated with a 600 mg loading dose of clopidogrel
followed by 75 mg/day clopidogrel plus 100 mg/day aspirin. Patients in group B
received a 180 mg loading dose of ticagrelor followed by 90 mg ticagrelor twice
daily plus 100 mg/day aspirin. Light transmission aggregometry was performed to
measure the platelet aggregation rate prior to and following 4 weeks of
anti-platelet drug treatment. In addition, the rate of cardiovascular events and
the adverse drug reactions were recorded within a 1-year treatment period.
Compared with the clopidogrel group, the rate of recurrent angina in the
ticagrelor group was significantly lower (P=0.05). However, the rate of dyspnea
in the ticagrelor group was significantly higher when compared with that in the
clopidogrel group (P=0.03). After 4 weeks of treatment, the reduction in the
platelet aggregation rate was significantly different between the two groups
(P<0.05). Therefore, ticagrelor, which is a novel antiplatelet aggregation drug,
may reduce the rate of the adverse cardiovascular events in ACS patients
following PCI, but a higher incidence of side-effects, such as dyspnea, may be
observed.