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10.3892/etm.2016.3184 http://scihub22266oqcxt.onion/10.3892/etm.2016.3184 C4887758!4887758 !27284338     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27284338 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Ther+Med 2016 ; 11 (6 ): 2495-2502 Nephropedia Template TP {{tp|p=27284338 |t=2016. Effects of a GSK-3? inhibitor on the renal expression levels of RANK, RANKL and NF-?B in a rat model of diabetic nephropathy |pdf=|usr=}}{{27284338 }} gab.com Text Effects of a GSK-3 inhibitor on the renal expression levels of RANK, RANKL and NF- B in a rat model of diabetic nephropathy JO: Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=27284338 #FOAvip The present study aimed to investigate the effects of glycogen synthase kinase-3? (GSK-3?) on the expression levels of receptor activator of nuclear factor (NF)-?B (RANK), RANK ligand (RANKL) and NF-?B in the renal tissues of rats modeling diabetic nephropathy (DN). The rats were allocated at random into three groups, as follows: Normal control group (NC), the DN model group (DNM group) and the DN model lithium chloride (LiCl) intervention group (DNI group). Urinary proteins were examined by staining with the Coomassie Brilliant Blue dye for 24 h. Histochemical analyses of kidney tissue sections were conducted using hematoxylin and eosin staining, after which the kidney pathology of the rats was observed. In addition, the mRNA and protein expression levels of GSK-3?, RANK, RANKL and NF-?B in the renal tissues were detected using reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, respectively. As compared with the NC group, the level of urinary protein was significantly increased in the DNM group (P<0.05); however, as compared with the DNM Group, the level of urinary protein at 12 weeks was significantly decreased in the DNI group (P<0.05). As compared with the NC group, marked pathological changes were detected, and the mRNA and protein expression levels of GSK-3?, RANK, RANKL and NF-?B were significantly increased, in the renal tissues of the DNM group. Conversely, pathological alterations in the renal tissues were attenuated, and the mRNA and protein expression levels of GSK-3?, RANK, RANKL and NF-?B were significantly decreased (P<0.05), in the DNI group, as compared with the DNM group. The results of the present study suggested that GSK-3?, RANK, RANKL and NF-?B may be crucially involved in the development of DN, and that LiCl may effectively attenuate DN by reducing the expression levels of GSK-3?, RANK, RANKL and NF-?B. Twit Text FOAVip Effects of a GSK-3 inhibitor on the renal expression levels of RANK, RANKL and NF- B in a rat model of diabetic nephropathy ????Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=27284338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27284338 #FOAvip English Wikipedia <ref>{{Cite pmid|27284338 }}</ref> Effects of a GSK-3? inhibitor on the renal expression levels of RANK, RANKL and NF-?B in a rat model of diabetic nephropathy #MMPMID27284338 Zhou YX ; Shi LX ; Yang H ; Long YG ; Meng LU ; Lv LS ; Zhang Y ; Yao H ; Li L ; Yu YN Exp Ther Med 2016[Jun]; 11 (6 ): 2495-2502 PMID27284338 show ga The present study aimed to investigate the effects of glycogen synthase kinase-3? (GSK-3?) on the expression levels of receptor activator of nuclear factor (NF)-?B (RANK), RANK ligand (RANKL) and NF-?B in the renal tissues of rats modeling diabetic nephropathy (DN). The rats were allocated at random into three groups, as follows: Normal control group (NC), the DN model group (DNM group) and the DN model lithium chloride (LiCl) intervention group (DNI group). Urinary proteins were examined by staining with the Coomassie Brilliant Blue dye for 24 h. Histochemical analyses of kidney tissue sections were conducted using hematoxylin and eosin staining, after which the kidney pathology of the rats was observed. In addition, the mRNA and protein expression levels of GSK-3?, RANK, RANKL and NF-?B in the renal tissues were detected using reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, respectively. As compared with the NC group, the level of urinary protein was significantly increased in the DNM group (P<0.05); however, as compared with the DNM Group, the level of urinary protein at 12 weeks was significantly decreased in the DNI group (P<0.05). As compared with the NC group, marked pathological changes were detected, and the mRNA and protein expression levels of GSK-3?, RANK, RANKL and NF-?B were significantly increased, in the renal tissues of the DNM group. Conversely, pathological alterations in the renal tissues were attenuated, and the mRNA and protein expression levels of GSK-3?, RANK, RANKL and NF-?B were significantly decreased (P<0.05), in the DNI group, as compared with the DNM group. The results of the present study suggested that GSK-3?, RANK, RANKL and NF-?B may be crucially involved in the development of DN, and that LiCl may effectively attenuate DN by reducing the expression levels of GSK-3?, RANK, RANKL and NF-?B. äEffects of a GSK-3? inhibitor on the renal expression levels of RANK, (epmc).pdf DeepDyve Pubget Overpricing