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10.1016/j.ceb.2016.01.011 http://scihub22266oqcxt.onion/10.1016/j.ceb.2016.01.011 C4887392!4887392!26895141     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Cell+Biol 2016 ; 40 (ä): 32-40 Nephropedia Template TP {{tp|p=26895141|t=2016. Squish and squeeze ? the nucleus as a physical barrier during migration in confining environments |pdf=|usr=}}{{26895141}} gab.com Text Squish and squeeze the nucleus as a physical barrier during migration in confining environments JO: Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26895141 #FOAvip From embryonic development to cancer metastasis, cell migration plays a central role in health and disease. It is increasingly becoming apparent that cells migrating in three-dimensional (3-D) environments exhibit some striking differences compared with their well-established 2-D counterparts. One key finding is the significant role the nucleus plays during 3-D migration: when cells move in confined spaces, the cell body and nucleus must deform to squeeze through available spaces, and the deformability of the large and relatively rigid nucleus can become rate-limiting. In this review, we highlight recent findings regarding the role of nuclear mechanics in 3-D migration, including factors that govern nuclear deformability, and emerging mechanisms by which cells apply cytoskeletal forces to the nucleus to facilitate nuclear translocation. Intriguingly, the ?physical barrier? imposed by the nucleus also impacts cytoplasmic dynamics that affect cell migration and signaling, and changes in nuclear structure resulting from the mechanical forces acting on the nucleus during 3-D migration could further alter cellular function. These findings have broad relevance to the migration of both normal and cancerous cells inside living tissues, and motivate further research into the molecular details by which cells move their nuclei, as well as the consequences of the mechanical stress on the nucleus. Twit Text FOAVip Squish and squeeze the nucleus as a physical barrier during migration in confining environments ????Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26895141 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26895141 #FOAvip English Wikipedia <ref>{{Cite pmid|26895141}}</ref> Squish and squeeze ? the nucleus as a physical barrier during migration in confining environments #MMPMID26895141 McGregor AL; Hsia CR; Lammerding J Curr Opin Cell Biol 2016[Jun]; 40 (ä): 32-40 PMID26895141show ga From embryonic development to cancer metastasis, cell migration plays a central role in health and disease. It is increasingly becoming apparent that cells migrating in three-dimensional (3-D) environments exhibit some striking differences compared with their well-established 2-D counterparts. One key finding is the significant role the nucleus plays during 3-D migration: when cells move in confined spaces, the cell body and nucleus must deform to squeeze through available spaces, and the deformability of the large and relatively rigid nucleus can become rate-limiting. In this review, we highlight recent findings regarding the role of nuclear mechanics in 3-D migration, including factors that govern nuclear deformability, and emerging mechanisms by which cells apply cytoskeletal forces to the nucleus to facilitate nuclear translocation. Intriguingly, the ?physical barrier? imposed by the nucleus also impacts cytoplasmic dynamics that affect cell migration and signaling, and changes in nuclear structure resulting from the mechanical forces acting on the nucleus during 3-D migration could further alter cellular function. These findings have broad relevance to the migration of both normal and cancerous cells inside living tissues, and motivate further research into the molecular details by which cells move their nuclei, as well as the consequences of the mechanical stress on the nucleus. äSquish and squeeze ? the nucleus as a physical barrier during migratio(epmc).pdf DeepDyve Pubget Overpricing