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10.1053/j.gastro.2016.02.066 http://scihub22266oqcxt.onion/10.1053/j.gastro.2016.02.066 C4887389!4887389!26928243     free     free     free       Gastroenterology 2016 ; 150 (8): 1769-77 Nephropedia Template TP {{tp|p=26928243|t=2016. Pathogenesis of Nonalcoholic Steatohepatitis |pdf=|usr=}}{{26928243}} gab.com Text Pathogenesis of Nonalcoholic Steatohepatitis JO: Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=26928243 #FOAvip Nonalcoholic steatohepatitis (NASH) is a necro-inflammatory response that ensues when hepatocytes are injured by lipids (lipotoxicity). NASH is a potential outcome of nonalcoholic fatty liver (NAFL), a condition that occurs when lipids accumulate in hepatocytes. NASH may be reversible, but it can also result in cirrhosis and primary liver cancer. We are beginning to learn about the mechanisms of progression of NAFL and NASH. NAFL does not inevitably lead to NASH, because NAFL is a heterogeneous condition. This heterogeneity exists because different types of lipids with different cytotoxic potential accumulate in the NAFL, and individuals with NAFL differ in their ability to defend against lipotoxicity. There are no tests that reliably predict which patients with NAFL will develop lipotoxicity. However, NASH encompasses the spectrum of wound-healing responses induced by lipotoxic hepatocytes. Differences in these wound-healing responses among individuals determine whether lipotoxic livers regenerate, leading to stabilization or resolution of NASH, or develop progressive scarring, cirrhosis, and possibly liver cancer. We review concepts that are central to the pathogenesis of NASH. Twit Text FOAVip Pathogenesis of Nonalcoholic Steatohepatitis ????Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=26928243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26928243 #FOAvip English Wikipedia <ref>{{Cite pmid|26928243}}</ref> Pathogenesis of Nonalcoholic Steatohepatitis #MMPMID26928243 Machado MV; Diehl AM Gastroenterology 2016[Jun]; 150 (8): 1769-77 PMID26928243show ga Nonalcoholic steatohepatitis (NASH) is a necro-inflammatory response that ensues when hepatocytes are injured by lipids (lipotoxicity). NASH is a potential outcome of nonalcoholic fatty liver (NAFL), a condition that occurs when lipids accumulate in hepatocytes. NASH may be reversible, but it can also result in cirrhosis and primary liver cancer. We are beginning to learn about the mechanisms of progression of NAFL and NASH. NAFL does not inevitably lead to NASH, because NAFL is a heterogeneous condition. This heterogeneity exists because different types of lipids with different cytotoxic potential accumulate in the NAFL, and individuals with NAFL differ in their ability to defend against lipotoxicity. There are no tests that reliably predict which patients with NAFL will develop lipotoxicity. However, NASH encompasses the spectrum of wound-healing responses induced by lipotoxic hepatocytes. Differences in these wound-healing responses among individuals determine whether lipotoxic livers regenerate, leading to stabilization or resolution of NASH, or develop progressive scarring, cirrhosis, and possibly liver cancer. We review concepts that are central to the pathogenesis of NASH. äPathogenesis of Nonalcoholic Steatohepatitis (epmc).pdf DeepDyve Pubget Overpricing