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Time-dependent toxicity of cadmium telluride quantum dots on liver and kidneys in
mice: histopathological changes with elevated free cadmium ions and hydroxyl
radicals
#MMPMID27307732
Wang M
; Wang J
; Sun H
; Han S
; Feng S
; Shi L
; Meng P
; Li J
; Huang P
; Sun Z
Int J Nanomedicine
2016[]; 11
(?): 2319-28
PMID27307732
show ga
A complete understanding of the toxicological behavior of quantum dots (QDs) in
vivo is of great importance and a prerequisite for their application in humans.
In contrast with the numerous cytotoxicity studies investigating QDs, only a few
in vivo studies of QDs have been reported, and the issue remains controversial.
Our study aimed to understand QD-mediated toxicity across different time points
and to explore the roles of free cadmium ions (Cd(2+)) and hydroxyl radicals
(·OH) in tissue damage. Male ICR mice were administered a single intravenous dose
(1.5 µmol/kg) of CdTe QDs, and liver and kidney function and morphology were
subsequently examined at 1, 7, 14, and 28 days. Furthermore, ·OH production in
the tissue was quantified by trapping · OH with salicylic acid (SA) as
2,3-dihydroxybenzoic acid (DHBA) and detecting it using a high-performance liquid
chromatography fluorescence method. We used the induction of tissue
metallothionein levels and 2,3-DHBA:SA ratios as markers for elevated Cd(2+) from
the degradation of QDs and ·OH generation in the tissue, respectively. Our
experimental results revealed that the QD-induced histopathological changes were
time-dependent with elevated Cd(2+) and ·OH, and could recover after a period of
time. The Cd(2+) and ·OH exhibited delayed effects in terms of histopathological
abnormalities. Histological assessments performed at multiple time points might
facilitate the evaluation of the biological safety of QDs.
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