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10.1016/S1877-1173(10)92004-8 http://scihub22266oqcxt.onion/10.1016/S1877-1173(10)92004-8 C4887107!4887107!20800817     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Prog+Mol+Biol+Transl+Sci 2010 ; 92 (ä): 65-100 Nephropedia Template TP {{tp|p=20800817|t=2010. Functional Development of the T Cell Receptor for Antigen |pdf=|usr=}}{{20800817}} gab.com Text Functional Development of the T Cell Receptor for Antigen JO: Prog Mol Biol Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=20800817 #FOAvip For over three decades now, the T cell receptor (TCR) for antigen has not ceased to challenge the imaginations of cellular and molecular immunologists alike. T cell antigen recognition transcends every aspect of adaptive immunity: it shapes the T cell repertoire in the thymus and directs T cell-mediated effector functions in the periphery, where it is also central to the induction of peripheral tolerance. Yet, despite its central position, there remain many questions unresolved: how can one TCR be specific for one particular peptide-major histocompatibility complex (pMHC) ligand while also binding other pMHC ligands with an immunologically relevant affinity? And how can a T cell?s extreme specificity (alterations of single methyl groups in their ligand can abrogate a response) and sensitivity (single agonist ligands on a cell surface are sufficient to trigger a measurable response) emerge from TCR?ligand interactions that are so low in affinity? Solving these questions is intimately tied to a fundamental understanding of molecular recognition dynamics within the many different contexts of various T cell?antigen presenting cell (APC) contacts: from the thymic APCs that shape the TCR repertoire and guide functional differentiation of developing T cells to the peripheral APCs that support homeostasis and provoke antigen responses in naïve, effector, memory, and regulatory T cells. Here, we discuss our recent findings relating to T cell antigen recognition and how this leads to the thymic development of foreign-antigen-responsive ??T cells. Twit Text FOAVip Functional Development of the T Cell Receptor for Antigen ????Prog Mol Biol Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=20800817 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20800817 #FOAvip English Wikipedia <ref>{{Cite pmid|20800817}}</ref> Functional Development of the T Cell Receptor for Antigen #MMPMID20800817 Ebert PJ; Li QJ; Huppa JB; Davis MM Prog Mol Biol Transl Sci 2010[]; 92 (ä): 65-100 PMID20800817show ga For over three decades now, the T cell receptor (TCR) for antigen has not ceased to challenge the imaginations of cellular and molecular immunologists alike. T cell antigen recognition transcends every aspect of adaptive immunity: it shapes the T cell repertoire in the thymus and directs T cell-mediated effector functions in the periphery, where it is also central to the induction of peripheral tolerance. Yet, despite its central position, there remain many questions unresolved: how can one TCR be specific for one particular peptide-major histocompatibility complex (pMHC) ligand while also binding other pMHC ligands with an immunologically relevant affinity? And how can a T cell?s extreme specificity (alterations of single methyl groups in their ligand can abrogate a response) and sensitivity (single agonist ligands on a cell surface are sufficient to trigger a measurable response) emerge from TCR?ligand interactions that are so low in affinity? Solving these questions is intimately tied to a fundamental understanding of molecular recognition dynamics within the many different contexts of various T cell?antigen presenting cell (APC) contacts: from the thymic APCs that shape the TCR repertoire and guide functional differentiation of developing T cells to the peripheral APCs that support homeostasis and provoke antigen responses in naïve, effector, memory, and regulatory T cells. Here, we discuss our recent findings relating to T cell antigen recognition and how this leads to the thymic development of foreign-antigen-responsive ??T cells. äFunctional Development of the T Cell Receptor for Antigen (epmc).pdf DeepDyve Pubget Overpricing