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10.1038/mt.2015.214 http://scihub22266oqcxt.onion/10.1038/mt.2015.214 C4886928!4886928!26675501     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Ther 2016 ; 24 (4): 707-18 Nephropedia Template TP {{tp|p=26675501|t=2016. Modulation of Protein?Protein Interactions for the Development of Novel Therapeutics |pdf=|usr=}}{{26675501}} gab.com Text Modulation of Protein Protein Interactions for the Development of Novel Therapeutics JO: Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26675501 #FOAvip Protein?protein interactions (PPIs) underlie most biological processes. An increasing interest to investigate the unexplored potential of PPIs in drug discovery is driven by the need to find novel therapeutic targets for a whole range of diseases with a high unmet medical need. To date, PPI inhibition with small molecules is the mechanism that has most often been explored, resulting in significant progress towards drug development. However, also PPI stabilization is gradually gaining ground. In this review, we provide a focused overview of a number of PPIs that control critical regulatory pathways and constitute targets for the design of novel therapeutics. We discuss PPI-modulating small molecules that are already pursued in clinical trials. In addition, we review a number of PPIs that are still under preclinical investigation but for which preliminary data support their use as therapeutic targets. Twit Text FOAVip Modulation of Protein Protein Interactions for the Development of Novel Therapeutics ????Mol Ther http://www.kidney.de/pget.php?&tw=1&pmid=26675501 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26675501 #FOAvip English Wikipedia <ref>{{Cite pmid|26675501}}</ref> Modulation of Protein?Protein Interactions for the Development of Novel Therapeutics #MMPMID26675501 Petta I; Lievens S; Libert C; Tavernier J; De Bosscher K Mol Ther 2016[Apr]; 24 (4): 707-18 PMID26675501show ga Protein?protein interactions (PPIs) underlie most biological processes. An increasing interest to investigate the unexplored potential of PPIs in drug discovery is driven by the need to find novel therapeutic targets for a whole range of diseases with a high unmet medical need. To date, PPI inhibition with small molecules is the mechanism that has most often been explored, resulting in significant progress towards drug development. However, also PPI stabilization is gradually gaining ground. In this review, we provide a focused overview of a number of PPIs that control critical regulatory pathways and constitute targets for the design of novel therapeutics. We discuss PPI-modulating small molecules that are already pursued in clinical trials. In addition, we review a number of PPIs that are still under preclinical investigation but for which preliminary data support their use as therapeutic targets. äModulation of Protein?Protein Interactions for the Development of Nove(epmc).pdf DeepDyve Pubget Overpricing