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10.4155/fmc.15.166 http://scihub22266oqcxt.onion/10.4155/fmc.15.166 C4886745!4886745!26689099     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Future+Med+Chem 2016 ; 8 (1): 73-86 Nephropedia Template TP {{tp|p=26689099|t=2016. Leaving the lysosome behind: novel developments in autophagy inhibition |pdf=|usr=}}{{26689099}} gab.com Text Leaving the lysosome behind: novel developments in autophagy inhibition JO: Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26689099 #FOAvip The search for a single silver bullet for the treatment of cancer has now been overshadowed by the identification of multiple therapeutic targets unique to each malignancy and even to each patient. In recent years, autophagy has emerged as one such therapeutic target. In response to both therapeutic and oncogenic stress, cancer cells upregulate and demonstrate an increased dependence upon this intracellular recycling process. Particularly in malignancies that currently lack targeted therapeutic options, autophagy inhibitors are the next hopeful prospects for the treatment of this disease. In this review, we discuss the rapid evolution of autophagy inhibitors from early lysosomotropic agents to next-generation lysosome-targeted drugs and beyond. Twit Text FOAVip Leaving the lysosome behind: novel developments in autophagy inhibition ????Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26689099 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26689099 #FOAvip English Wikipedia <ref>{{Cite pmid|26689099}}</ref> Leaving the lysosome behind: novel developments in autophagy inhibition #MMPMID26689099 Solitro AR; MacKeigan JP Future Med Chem 2016[Jan]; 8 (1): 73-86 PMID26689099show ga The search for a single silver bullet for the treatment of cancer has now been overshadowed by the identification of multiple therapeutic targets unique to each malignancy and even to each patient. In recent years, autophagy has emerged as one such therapeutic target. In response to both therapeutic and oncogenic stress, cancer cells upregulate and demonstrate an increased dependence upon this intracellular recycling process. Particularly in malignancies that currently lack targeted therapeutic options, autophagy inhibitors are the next hopeful prospects for the treatment of this disease. In this review, we discuss the rapid evolution of autophagy inhibitors from early lysosomotropic agents to next-generation lysosome-targeted drugs and beyond. äLeaving the lysosome behind: novel developments in autophagy inhibitio(epmc).pdf DeepDyve Pubget Overpricing