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10.1097/QCO.0b013e32833bc1b0 http://scihub22266oqcxt.onion/10.1097/QCO.0b013e32833bc1b0 C4886735!4886735!20581672     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Infect+Dis 2010 ; 23 (4): 359-64 Nephropedia Template TP {{tp|p=20581672|t=2010. Adult-Onset Presentations of Genetic Immunodeficiencies: Genes Can Throw Slow Curves |pdf=|usr=}}{{20581672}} gab.com Text Adult-Onset Presentations of Genetic Immunodeficiencies: Genes Can Throw Slow Curves JO: Curr Opin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=20581672 #FOAvip Purpose of Review: The molecular and genetic mechanisms behind adult presentations of primary immunodeficiency diseases are examined, with particular emphasis on cases where this was heralded by severe, recurrent or opportunistic infection. Recent Findings: A detailed analysis over the last two decades of the relationship between genotype and clinical phenotype for a number of genetic immunodeficiencies has revealed multiple mechanisms that can account for the delayed presentation of genetic disorders that typically present in childhood, including hypomorphic gene mutations and X-linked gene mutations with age-related skewing in random X-chromosome inactivation. Adult-onset presentations of chronic granulomatous disease, X-linked agammaglobulinemia, interleukin-12/T helper 1/interferon-gamma and interleukin-23/T helper 17/interleukin-17 pathway defects, and X-linked lymphoproliferative disorder are used to illustrate these mechanisms. Finally, certain genetic types of common variable immunodeficiency are used to illustrate that inherited null mutations can take decades to manifest immunologically. Summary: Both genetic mechanisms and environmental factors can account for adult-onset infectious and non-infectious complications as manifestations of disorders that typically present in childhood. This emphasizes the potential complexity in the relationship between genotype and phenotype with natural human mutations. Twit Text FOAVip Adult-Onset Presentations of Genetic Immunodeficiencies: Genes Can Throw Slow Curves ????Curr Opin Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=20581672 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20581672 #FOAvip English Wikipedia <ref>{{Cite pmid|20581672}}</ref> Adult-Onset Presentations of Genetic Immunodeficiencies: Genes Can Throw Slow Curves #MMPMID20581672 Nelson KS; Lewis DB Curr Opin Infect Dis 2010[Aug]; 23 (4): 359-64 PMID20581672show ga Purpose of Review: The molecular and genetic mechanisms behind adult presentations of primary immunodeficiency diseases are examined, with particular emphasis on cases where this was heralded by severe, recurrent or opportunistic infection. Recent Findings: A detailed analysis over the last two decades of the relationship between genotype and clinical phenotype for a number of genetic immunodeficiencies has revealed multiple mechanisms that can account for the delayed presentation of genetic disorders that typically present in childhood, including hypomorphic gene mutations and X-linked gene mutations with age-related skewing in random X-chromosome inactivation. Adult-onset presentations of chronic granulomatous disease, X-linked agammaglobulinemia, interleukin-12/T helper 1/interferon-gamma and interleukin-23/T helper 17/interleukin-17 pathway defects, and X-linked lymphoproliferative disorder are used to illustrate these mechanisms. Finally, certain genetic types of common variable immunodeficiency are used to illustrate that inherited null mutations can take decades to manifest immunologically. Summary: Both genetic mechanisms and environmental factors can account for adult-onset infectious and non-infectious complications as manifestations of disorders that typically present in childhood. This emphasizes the potential complexity in the relationship between genotype and phenotype with natural human mutations. äAdult-Onset Presentations of Genetic Immunodeficiencies: Genes Can Thr(epmc).pdf DeepDyve Pubget Overpricing