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10.1016/j.bbamcr.2016.03.021 http://scihub22266oqcxt.onion/10.1016/j.bbamcr.2016.03.021 C4886714!4886714 !27033521     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27033521 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochim+Biophys+Acta 2016 ; 1863 (6 Pt A ): 1307-18 Nephropedia Template TP {{tp|p=27033521 |t=2016. Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation |pdf=|usr=}}{{27033521 }} gab.com Text Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=27033521 #FOAvip Biogenesis of the primary cilium, a cellular organelle mediating various signaling pathways, is generally coordinated with cell cycle exit/re-entry. Although the dynamic cell cycle-associated profile of the primary cilium has been largely accepted, the mechanism governing the link between ciliogenesis and cell cycle progression has been poorly understood. Using a human genome-wide RNAi screen, we identify genes encoding subunits of the spliceosome and proteasome as novel regulators of ciliogenesis. We demonstrate that 1) the mRNA processing-related hits are essential for RNA expression of molecules acting in cilia disassembly, such as AURKA and PLK1, and 2) the ubiquitin-proteasome systems (UPS)-involved hits are necessary for proteolysis of molecules acting in cilia assembly, such as IFT88 and CPAP. In particular, we show that these screen hit-associated mechanisms are crucial for both cilia assembly and cell cycle arrest in response to serum withdrawal. Finally, our data suggest that the mRNA processing mechanism may modulate the UPS-dependent decay of cilia assembly regulators to control ciliary resorption-coupled cell cycle re-entry. Twit Text FOAVip Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=27033521 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27033521 #FOAvip English Wikipedia <ref>{{Cite pmid|27033521 }}</ref> Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation #MMPMID27033521 Kim JH ; Ki SM ; Joung JG ; Scott E ; Heynen-Genel S ; Aza-Blanc P ; Kwon CH ; Kim J ; Gleeson JG ; Lee JE Biochim Biophys Acta 2016[Jun]; 1863 (6 Pt A ): 1307-18 PMID27033521 show ga Biogenesis of the primary cilium, a cellular organelle mediating various signaling pathways, is generally coordinated with cell cycle exit/re-entry. Although the dynamic cell cycle-associated profile of the primary cilium has been largely accepted, the mechanism governing the link between ciliogenesis and cell cycle progression has been poorly understood. Using a human genome-wide RNAi screen, we identify genes encoding subunits of the spliceosome and proteasome as novel regulators of ciliogenesis. We demonstrate that 1) the mRNA processing-related hits are essential for RNA expression of molecules acting in cilia disassembly, such as AURKA and PLK1, and 2) the ubiquitin-proteasome systems (UPS)-involved hits are necessary for proteolysis of molecules acting in cilia assembly, such as IFT88 and CPAP. In particular, we show that these screen hit-associated mechanisms are crucial for both cilia assembly and cell cycle arrest in response to serum withdrawal. Finally, our data suggest that the mRNA processing mechanism may modulate the UPS-dependent decay of cilia assembly regulators to control ciliary resorption-coupled cell cycle re-entry. |*RNA Interference [MESH] |Blotting, Western [MESH] |Cell Cycle Checkpoints/drug effects/*genetics [MESH] |Cell Cycle/*genetics [MESH] |Cell Line [MESH] |Cilia/*metabolism/physiology [MESH] |Cluster Analysis [MESH] |Culture Media, Serum-Free/pharmacology [MESH] |Gene Expression Profiling/methods [MESH] |Gene Regulatory Networks/genetics [MESH] |Genome, Human/*genetics [MESH] |Humans [MESH] |Luminescent Proteins/genetics/metabolism [MESH] |Microscopy, Confocal [MESH] |Models, Genetic [MESH] |Morphogenesis/genetics [MESH] |Proteome/genetics/metabolism [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Genome-wide screen identifies novel machineries required for both cili(epmc).pdf DeepDyve Pubget Overpricing