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10.1038/srep27051 http://scihub22266oqcxt.onion/10.1038/srep27051 C4886686!4886686 !27243216     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27243216 &cmd=llinks): Failed to open stream: HTTP request failed! 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LPS/TLR4 Signaling Enhances TGF-? Response Through Downregulating BAMBI During Prostatic Hyperplasia |pdf=|usr=}}{{27243216 }} gab.com Text LPS/TLR4 Signaling Enhances TGF- Response Through Downregulating BAMBI During Prostatic Hyperplasia JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27243216 #FOAvip Compelling evidence suggests that benign prostatic hyperplasia (BPH) development involves accumulation of mesenchymal-like cells derived from the prostatic epithelium by epithelial-mesenchymal transition (EMT). Transforming growth factor (TGF)-? induces EMT phenotypes with low E-cadherin and high vimentin expression in prostatic epithelial cells. Here we report that LPS/TLR4 signalling induces down-regulation of the bone morphogenic protein and activin membrane-bound inhibitor (BAMBI), which enhances TGF-? signalling in the EMT process during prostatic hyperplasia. Additionally, we found that the mean TLR4 staining score was significantly higher in BPH tissues with inflammation compared with BPH tissues without inflammation (5.13?±?1.21 and 2.96?±?0.73, respectively; P?<?0.001). Moreover, patients with inflammatory infiltrate were more likely to have a higher age (P?=?0.020), BMI (P?=?0.026), prostate volume (P?=?0.024), total IPSS score (P?=?0.009) and IPSS-S (P?<?0.001). Pearson's correlation coefficient and multiple regression analyses demonstrated that TLR4 mRNA expression level was significantly positively associated with age, BMI, serum PSA levels, urgency and nocturia subscores of IPSS in the inflammatory group. These findings provide new insights into the TLR4-amplified EMT process and the association between TLR4 levels and storage LUTS, suggesting chronic inflammation as vital to the pathogenesis of BPH. Twit Text FOAVip LPS/TLR4 Signaling Enhances TGF- Response Through Downregulating BAMBI During Prostatic Hyperplasia ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27243216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27243216 #FOAvip English Wikipedia <ref>{{Cite pmid|27243216 }}</ref> LPS/TLR4 Signaling Enhances TGF-? Response Through Downregulating BAMBI During Prostatic Hyperplasia #MMPMID27243216 He Y ; Ou Z ; Chen X ; Zu X ; Liu L ; Li Y ; Cao Z ; Chen M ; Chen Z ; Chen H ; Qi L ; Wang L Sci Rep 2016[May]; 6 (ä): 27051 PMID27243216 show ga Compelling evidence suggests that benign prostatic hyperplasia (BPH) development involves accumulation of mesenchymal-like cells derived from the prostatic epithelium by epithelial-mesenchymal transition (EMT). Transforming growth factor (TGF)-? induces EMT phenotypes with low E-cadherin and high vimentin expression in prostatic epithelial cells. Here we report that LPS/TLR4 signalling induces down-regulation of the bone morphogenic protein and activin membrane-bound inhibitor (BAMBI), which enhances TGF-? signalling in the EMT process during prostatic hyperplasia. Additionally, we found that the mean TLR4 staining score was significantly higher in BPH tissues with inflammation compared with BPH tissues without inflammation (5.13?±?1.21 and 2.96?±?0.73, respectively; P? |*Signal Transduction [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Body Mass Index [MESH] |Cell Line [MESH] |Epithelial Cells/drug effects/metabolism/pathology [MESH] |Epithelial-Mesenchymal Transition/*drug effects/genetics [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Inflammation [MESH] |Kallikreins/blood/genetics [MESH] |Lipopolysaccharides/*pharmacology [MESH] |Male [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Middle Aged [MESH] |Prostate-Specific Antigen/blood/genetics [MESH] |Prostate/drug effects/metabolism/pathology/surgery [MESH] |Prostatic Hyperplasia/genetics/*metabolism/pathology/surgery [MESH] |Toll-Like Receptor 4/genetics/*metabolism [MESH] |Transforming Growth Factor beta/genetics/metabolism/pharmacology [MESH]LPS/TLR4 Signaling Enhances TGF-? Response Through Downregulating BAMB(epmc).pdf DeepDyve Pubget Overpricing