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10.1084/jem.20152003 http://scihub22266oqcxt.onion/10.1084/jem.20152003 C4886367!4886367 !27217539     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27217539 &cmd=llinks): Failed to open stream: HTTP request failed! 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Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development |pdf=|usr=}}{{27217539 }} gab.com Text Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27217539 #FOAvip The generation of high-affinity antibodies requires germinal center (GC) development and differentiation of long-lived plasma cells in a multilayered process that is tightly controlled by the activity of multiple transcription factors. Here, we reveal a new layer of complexity by demonstrating that dynamic changes in Id3 and E-protein activity govern both GC and plasma cell differentiation. We show that down-regulation of Id3 in B cells is essential for releasing E2A and E2-2, which in a redundant manner are required for antigen-induced B cell differentiation. We demonstrate that this pathway controls the expression of multiple key factors, including Blimp1, Xbp1, and CXCR4, and is therefore critical for establishing the transcriptional network that controls GC B cell and plasma cell differentiation. Twit Text FOAVip Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27217539 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27217539 #FOAvip English Wikipedia <ref>{{Cite pmid|27217539 }}</ref> Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development #MMPMID27217539 Gloury R ; Zotos D ; Zuidscherwoude M ; Masson F ; Liao Y ; Hasbold J ; Corcoran LM ; Hodgkin PD ; Belz GT ; Shi W ; Nutt SL ; Tarlinton DM ; Kallies A J Exp Med 2016[May]; 213 (6 ): 1095-111 PMID27217539 show ga The generation of high-affinity antibodies requires germinal center (GC) development and differentiation of long-lived plasma cells in a multilayered process that is tightly controlled by the activity of multiple transcription factors. Here, we reveal a new layer of complexity by demonstrating that dynamic changes in Id3 and E-protein activity govern both GC and plasma cell differentiation. We show that down-regulation of Id3 in B cells is essential for releasing E2A and E2-2, which in a redundant manner are required for antigen-induced B cell differentiation. We demonstrate that this pathway controls the expression of multiple key factors, including Blimp1, Xbp1, and CXCR4, and is therefore critical for establishing the transcriptional network that controls GC B cell and plasma cell differentiation. |Animals [MESH] |Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics/*immunology [MESH] |Basic Helix-Loop-Helix Transcription Factors/genetics/*immunology [MESH] |Cell Differentiation/genetics/*immunology [MESH] |Germinal Center/*immunology [MESH] |Inhibitor of Differentiation Proteins/genetics/*immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Plasma Cells/*immunology [MESH] |Positive Regulatory Domain I-Binding Factor 1 [MESH] |Receptors, CXCR4/genetics/immunology [MESH] |Transcription Factor 4 [MESH] |Transcription Factors/genetics/immunology [MESH]Dynamic changes in Id3 and E-protein activity orchestrate germinal cen(epmc).pdf DeepDyve Pubget Overpricing