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10.1084/jem.20151869 http://scihub22266oqcxt.onion/10.1084/jem.20151869 C4886365!4886365 !27139492     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27139492 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2016 ; 213 (6 ): 967-78 Nephropedia Template TP {{tp|p=27139492 |t=2016. Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites |pdf=|usr=}}{{27139492 }} gab.com Text Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27139492 #FOAvip Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice. We found spontaneous anti-insulin germinal center (GC) formation throughout lymphoid tissues with GC B cells binding insulin. Moreover, because of the nature of the insulin epitope recognized by the T cells, it was evident that GC B cells presented a broader repertoire of insulin epitopes. Such broader recognition was reproduced by activating naive B cells ex vivo with a combination of CD40 ligand and interleukin 4. Thus, insulin immunoreactivity extends beyond the pancreatic lymph node-islets of Langerhans axis and indicates that circulating insulin, despite its very low levels, can have an influence on diabetogenesis. Twit Text FOAVip Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27139492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27139492 #FOAvip English Wikipedia <ref>{{Cite pmid|27139492 }}</ref> Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites #MMPMID27139492 Wan X ; Thomas JW ; Unanue ER J Exp Med 2016[May]; 213 (6 ): 967-78 PMID27139492 show ga Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice. We found spontaneous anti-insulin germinal center (GC) formation throughout lymphoid tissues with GC B cells binding insulin. Moreover, because of the nature of the insulin epitope recognized by the T cells, it was evident that GC B cells presented a broader repertoire of insulin epitopes. Such broader recognition was reproduced by activating naive B cells ex vivo with a combination of CD40 ligand and interleukin 4. Thus, insulin immunoreactivity extends beyond the pancreatic lymph node-islets of Langerhans axis and indicates that circulating insulin, despite its very low levels, can have an influence on diabetogenesis. |Animals [MESH] |Antigen Presentation/genetics/*immunology [MESH] |B-Lymphocytes/*immunology/pathology [MESH] |CD40 Antigens/genetics/immunology [MESH] |Diabetes Mellitus, Type 1/genetics/*immunology/pathology [MESH] |Germinal Center/*immunology/pathology [MESH] |Immunoglobulin Class Switching/genetics/*immunology [MESH] |Insulin/genetics/*immunology [MESH] |Interleukin-4/genetics/immunology [MESH] |Islets of Langerhans/immunology/pathology [MESH] |Mice [MESH] |Mice, Knockout [MESH]Class-switched anti-insulin antibodies originate from unconventional a(epmc).pdf DeepDyve Pubget Overpricing