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10.1084/jem.20151682 http://scihub22266oqcxt.onion/10.1084/jem.20151682 C4886361!4886361 !27162138     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27162138 &cmd=llinks): Failed to open stream: HTTP request failed! 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Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses |pdf=|usr=}}{{27162138 }} gab.com Text Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27162138 #FOAvip Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and selection. Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHCII) proteins. How GC B cells are able to rapidly and repeatedly transition between mutating their B cell receptor genes and then being selected shortly after is not known. We report that MHCII surface levels and degradation are dynamically regulated in GC B cells. Through ectopic expression of a photoconvertible MHCII-mKikGR chimeric gene, we found that individual GC B cells differed in the rates of MHCII protein turnover. Fluctuations in surface MHCII levels were dependent on ubiquitination and the E3 ligase March1. Increases in March1 expression in centroblasts correlated with decreases in surface MHCII levels, whereas CD83 expression in centrocytes helped to stabilize MHCII at that stage. Defects in MHCII ubiquitination caused GC B cells to accumulate greater amounts of a specific peptide-MHCII (pMHCII), suggesting that MHCII turnover facilitates the replacement of old complexes. We propose that pMHCII complexes are periodically targeted for degradation in centroblasts to favor the presentation of recently acquired antigens, thereby promoting the fidelity and efficiency of selection. Twit Text FOAVip Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27162138 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27162138 #FOAvip English Wikipedia <ref>{{Cite pmid|27162138 }}</ref> Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses #MMPMID27162138 Bannard O ; McGowan SJ ; Ersching J ; Ishido S ; Victora GD ; Shin JS ; Cyster JG J Exp Med 2016[May]; 213 (6 ): 993-1009 PMID27162138 show ga Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and selection. Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHCII) proteins. How GC B cells are able to rapidly and repeatedly transition between mutating their B cell receptor genes and then being selected shortly after is not known. We report that MHCII surface levels and degradation are dynamically regulated in GC B cells. Through ectopic expression of a photoconvertible MHCII-mKikGR chimeric gene, we found that individual GC B cells differed in the rates of MHCII protein turnover. Fluctuations in surface MHCII levels were dependent on ubiquitination and the E3 ligase March1. Increases in March1 expression in centroblasts correlated with decreases in surface MHCII levels, whereas CD83 expression in centrocytes helped to stabilize MHCII at that stage. Defects in MHCII ubiquitination caused GC B cells to accumulate greater amounts of a specific peptide-MHCII (pMHCII), suggesting that MHCII turnover facilitates the replacement of old complexes. We propose that pMHCII complexes are periodically targeted for degradation in centroblasts to favor the presentation of recently acquired antigens, thereby promoting the fidelity and efficiency of selection. |*Proteolysis [MESH] |Animals [MESH] |Antigens, CD/genetics/immunology [MESH] |B-Lymphocytes/*immunology/pathology [MESH] |CD83 Antigen [MESH] |Gene Expression Regulation/immunology [MESH] |Germinal Center/*immunology/pathology [MESH] |Histocompatibility Antigens Class II/genetics/*immunology [MESH] |Immunoglobulins/genetics/immunology [MESH] |Membrane Glycoproteins/genetics/immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Ubiquitin-Protein Ligases/genetics/immunology [MESH] |Ubiquitin/genetics/*immunology [MESH]Ubiquitin-mediated fluctuations in MHC class II facilitate efficient g(epmc).pdf DeepDyve Pubget Overpricing