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10.1084/jem.20151229

http://scihub22266oqcxt.onion/10.1084/jem.20151229
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C4886359!4886359!27162139
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suck abstract from ncbi


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pmid27162139      J+Exp+Med 2016 ; 213 (6): 1029-46
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  • Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4 #MMPMID27162139
  • Lear T; McKelvey AC; Rajbhandari S; Dunn SR; Coon TA; Connelly W; Zhao JY; Kass DJ; Zhang Y; Liu Y; Chen BB
  • J Exp Med 2016[May]; 213 (6): 1029-46 PMID27162139show ga
  • Lear et al. report a novel molecular pathway in which Fibrosis Inducing E3 Ligase 1 (FIEL1) regulates TGF? and fibrosis pathway through SUMO-E3 ligase PIAS4. They also develop a small molecule inhibitor toward FIEL1 that is highly effective in ameliorating fibrosis in mice.
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