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10.1084/jem.20151218 http://scihub22266oqcxt.onion/10.1084/jem.20151218 C4886358!4886358 !27139489     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27139489 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2016 ; 213 (6 ): 1079-93 Nephropedia Template TP {{tp|p=27139489 |t=2016. Interferon-? facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance |pdf=|usr=}}{{27139489 }} gab.com Text Interferon- facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27139489 #FOAvip Persistent exposure to liver pathogens leads to systemic antigen-specific tolerance, a major cause of chronicity during hepatotropic infection. The mechanism regarding how this systemic tolerance is maintained remains poorly elucidated. In a well established mouse model of hepatitis B virus (HBV) persistence-induced systemic tolerance, we observed that interferon-? (IFN-?) deficiency led to complete loss of tolerance, resulting in robust anti-HBV responses upon peripheral vaccination. The recovery of vaccine-induced anti-HBV responses was mainly caused by the retained antigen-specific CD4(+) T cells rather than decreased functional inhibitory cells in the periphery. Mechanistically, HBV persistence induced sustained hepatic CD4(+) T cell-derived IFN-? production. IFN-? was found to promote CXCL9 secretion from liver-resident macrophages. This T cell chemokine facilitated the retention of antiviral CD4(+) T cells in the liver in a CXCR3-dependent manner. Hepatic sequestrated antiviral CD4(+) T cells subsequently underwent local apoptotic elimination partially via cytotoxic T lymphocyte-associated protein 4 ligation. These findings reveal an unexpected tolerogenic role for IFN-? during viral persistence in the liver, providing new mechanistic insights regarding the maintenance of systemic antigen-specific tolerance during HBV persistence. Twit Text FOAVip Interferon- facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27139489 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27139489 #FOAvip English Wikipedia <ref>{{Cite pmid|27139489 }}</ref> Interferon-? facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance #MMPMID27139489 Zeng Z ; Li L ; Chen Y ; Wei H ; Sun R ; Tian Z J Exp Med 2016[May]; 213 (6 ): 1079-93 PMID27139489 show ga Persistent exposure to liver pathogens leads to systemic antigen-specific tolerance, a major cause of chronicity during hepatotropic infection. The mechanism regarding how this systemic tolerance is maintained remains poorly elucidated. In a well established mouse model of hepatitis B virus (HBV) persistence-induced systemic tolerance, we observed that interferon-? (IFN-?) deficiency led to complete loss of tolerance, resulting in robust anti-HBV responses upon peripheral vaccination. The recovery of vaccine-induced anti-HBV responses was mainly caused by the retained antigen-specific CD4(+) T cells rather than decreased functional inhibitory cells in the periphery. Mechanistically, HBV persistence induced sustained hepatic CD4(+) T cell-derived IFN-? production. IFN-? was found to promote CXCL9 secretion from liver-resident macrophages. This T cell chemokine facilitated the retention of antiviral CD4(+) T cells in the liver in a CXCR3-dependent manner. Hepatic sequestrated antiviral CD4(+) T cells subsequently underwent local apoptotic elimination partially via cytotoxic T lymphocyte-associated protein 4 ligation. These findings reveal an unexpected tolerogenic role for IFN-? during viral persistence in the liver, providing new mechanistic insights regarding the maintenance of systemic antigen-specific tolerance during HBV persistence. |*Immune Tolerance [MESH] |Animals [MESH] |CD4-Positive T-Lymphocytes/*immunology/pathology [MESH] |Chemokine CXCL9/genetics/immunology [MESH] |Disease Models, Animal [MESH] |Hepatitis B virus/*immunology [MESH] |Hepatitis B/genetics/*immunology/pathology/virology [MESH] |Interferon-gamma/genetics/*immunology [MESH] |Liver/*immunology/virology [MESH] |Male [MESH] |Mice [MESH]Interferon-? facilitates hepatic antiviral T cell retention for the ma(epmc).pdf DeepDyve Pubget Overpricing