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10.1093/jb/mvv124 http://scihub22266oqcxt.onion/10.1093/jb/mvv124 C4885935!4885935!26711238     free     free     free       J+Biochem 2016 ; 159 (4): 387-92 Nephropedia Template TP {{tp|p=26711238|t=2016. Regulation of bone metabolism by Wnt signals |pdf=|usr=}}{{26711238}} gab.com Text Regulation of bone metabolism by Wnt signals JO: J Biochem http://www.kidney.de/pget.php?&tw=1&pmid=26711238 #FOAvip Wnt ligands play a central role in the development and homeostasis of various organs through ?-catenin-dependent and -independent signalling. The crucial roles of Wnt/?-catenin signals in bone mass have been established by a large number of studies since the discovery of a causal link between mutations in the low-density lipoprotein receptor-related protein 5 (Lrp5) gene and alternations in human bone mass. The activation of Wnt/?-catenin signalling induces the expression of osterix, a transcription factor, which promotes osteoblast differentiation. Furthermore, this signalling induces the expression of osteoprotegerin, an osteoclast inhibitory factor in osteoblast-lineage cells to prevent bone resorption. Recent studies have also shown that Wnt5a, a typical non-canonical Wnt ligand, enhanced osteoclast formation. In contrast, Wnt16 inhibited osteoclast formation through ?-catenin-independent signalling. In this review, we discussed the current understanding of the Wnt signalling molecules involved in bone formation and resorption. Twit Text FOAVip Regulation of bone metabolism by Wnt signals ????J Biochem http://www.kidney.de/pget.php?&tw=1&pmid=26711238 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26711238 #FOAvip English Wikipedia <ref>{{Cite pmid|26711238}}</ref> Regulation of bone metabolism by Wnt signals #MMPMID26711238 Kobayashi Y; Uehara S; Udagawa N; Takahashi N J Biochem 2016[Apr]; 159 (4): 387-92 PMID26711238show ga Wnt ligands play a central role in the development and homeostasis of various organs through ?-catenin-dependent and -independent signalling. The crucial roles of Wnt/?-catenin signals in bone mass have been established by a large number of studies since the discovery of a causal link between mutations in the low-density lipoprotein receptor-related protein 5 (Lrp5) gene and alternations in human bone mass. The activation of Wnt/?-catenin signalling induces the expression of osterix, a transcription factor, which promotes osteoblast differentiation. Furthermore, this signalling induces the expression of osteoprotegerin, an osteoclast inhibitory factor in osteoblast-lineage cells to prevent bone resorption. Recent studies have also shown that Wnt5a, a typical non-canonical Wnt ligand, enhanced osteoclast formation. In contrast, Wnt16 inhibited osteoclast formation through ?-catenin-independent signalling. In this review, we discussed the current understanding of the Wnt signalling molecules involved in bone formation and resorption. äRegulation of bone metabolism by Wnt signals (epmc).pdf DeepDyve Pubget Overpricing