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10.1016/j.celrep.2016.04.062 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.062 C4885023!4885023!27184855     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (8): 1648-59 Nephropedia Template TP {{tp|p=27184855|t=2016. TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion |pdf=|usr=}}{{27184855}} gab.com Text TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27184855 #FOAvip Collagen is the most abundant protein in the animal kingdom. It is of fundamental importance during development for cell differentiation and tissue morphogenesis as well as in pathological processes such as fibrosis and cancer cell migration. However, our understanding of the mechanisms of procollagen secretion remains limited. Here, we show that TFG organizes transitional ER (tER) and ER exit sites (ERESs) into larger structures. Depletion of TFG results in dispersion of tER elements that remain associated with individual ER-Golgi intermediate compartments (ERGICs) as largely functional ERESs. We show that TFG is not required for the transport and packaging of small soluble cargoes but is necessary for the export of procollagen from the ER. Our work therefore suggests a key relationship between the structure and function of ERESs and a central role for TFG in optimizing COPII assembly for procollagen export. Twit Text FOAVip TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27184855 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27184855 #FOAvip English Wikipedia <ref>{{Cite pmid|27184855}}</ref> TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion #MMPMID27184855 McCaughey J; Miller V; Stevenson N; Brown A; Budnik A; Heesom K; Alibhai D; Stephens D Cell Rep 2016[May]; 15 (8): 1648-59 PMID27184855show ga Collagen is the most abundant protein in the animal kingdom. It is of fundamental importance during development for cell differentiation and tissue morphogenesis as well as in pathological processes such as fibrosis and cancer cell migration. However, our understanding of the mechanisms of procollagen secretion remains limited. Here, we show that TFG organizes transitional ER (tER) and ER exit sites (ERESs) into larger structures. Depletion of TFG results in dispersion of tER elements that remain associated with individual ER-Golgi intermediate compartments (ERGICs) as largely functional ERESs. We show that TFG is not required for the transport and packaging of small soluble cargoes but is necessary for the export of procollagen from the ER. Our work therefore suggests a key relationship between the structure and function of ERESs and a central role for TFG in optimizing COPII assembly for procollagen export. äTFG Promotes Organization of Transitional ER and Efficient Collagen Se(epmc).pdf DeepDyve Pubget Overpricing