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The prognostic effects of tumor infiltrating regulatory T cells and myeloid
derived suppressor cells assessed by multicolor flow cytometry in gastric cancer
patients
#MMPMID26799288
Choi HS
; Ha SY
; Kim HM
; Ahn SM
; Kang MS
; Kim KM
; Choi MG
; Lee JH
; Sohn TS
; Bae JM
; Kim S
; Kang ES
Oncotarget
2016[Feb]; 7
(7
): 7940-51
PMID26799288
show ga
The prognostic effects of tumor infiltrating lymphocytes (TILs), especially
regulatory T cells (Tregs) and myeloid derived suppressing cells (MDSCs) are
inconclusive in gastric cancers. We investigated the frequencies of TILs
including CD8+ T cells, CD45+CD4+CD25± FOXP3+ Tregs, CD45+CD11b+ CD14+ HLA-DR-
MDSCs in 28 gastric cancer tissues by using multicolor flow cytometry. In gastric
cancer tissue, the percentage of Tregs among the CD4+ T cell subset was
substantially increased compared to that of Tregs among peripheral blood CD4+ T
cells from the controls. High frequency of CD8+ T cells among CD3+ T cells
correlated with increased overall survival (OS) (p = 0.005). High frequency of
Tregs among CD4+ T cells correlated with increased OS (p < 0.001), and
disease-free survival (DFS) (p = 0.039) and was an independent prognostic factor
in OS (Hazard ratio: 0.047; 95% confidence interval, 0.006-0.372; p = 0.004).
High frequency of MDSCs among total examined cells correlated with decreased OS
(p = 0.027) and was an independent prognostic factor in OS (Hazard ratio 8.601;
95% confidence interval, 1.240-59.678; p = 0.029). We have demonstrated that high
levels of Tregs among tumor-infiltrating CD4+ T cells were favorable, but an
increased proportion of MDSCs was an adverse independent prognostic factor in
gastric cancer. Our results may provide important insights for future
immunotherapy in gastric cancer.
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