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10.1038/nrm4074 http://scihub22266oqcxt.onion/10.1038/nrm4074 C4884795!4884795!26490400     free     free     free       Nat+Rev+Mol+Cell+Biol 2015 ; 16 (11): 678-89 Nephropedia Template TP {{tp|p=26490400|t=2015. Transcriptional Regulation of Hepatic Lipogenesis |pdf=|usr=}}{{26490400}} gab.com Text Transcriptional Regulation of Hepatic Lipogenesis JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26490400 #FOAvip Fatty acid and fat synthesis in liver is a highly regulated metabolic pathway critical for energy distribution. Having common features at their promoter regions, lipogenic genes are coordinately regulated at the transcription level. Transcription factors, such as USF, SREBP-1c, LXR and ChREBP play critical roles in this process. Recently, insights have been gained into how various signaling pathways regulate these transcription factors. After feeding, high blood glucose and insulin induce lipogenic genes through several pathways, including DNA-PK, aPKC and Akt-mTOR. Various transcription factors and coregulators undergo specific modifications, such as phosphorylation, acetylation, or ubiquitination, which affect their function, stability, or localization. Dysregulation of lipogenesis can contribute to hepatosteatosis, which is associated with obesity and insulin resistance. Twit Text FOAVip Transcriptional Regulation of Hepatic Lipogenesis ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26490400 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26490400 #FOAvip English Wikipedia <ref>{{Cite pmid|26490400}}</ref> Transcriptional Regulation of Hepatic Lipogenesis #MMPMID26490400 Wang Y; Viscarra J; Kim SJ; Sul HS Nat Rev Mol Cell Biol 2015[Nov]; 16 (11): 678-89 PMID26490400show ga Fatty acid and fat synthesis in liver is a highly regulated metabolic pathway critical for energy distribution. Having common features at their promoter regions, lipogenic genes are coordinately regulated at the transcription level. Transcription factors, such as USF, SREBP-1c, LXR and ChREBP play critical roles in this process. Recently, insights have been gained into how various signaling pathways regulate these transcription factors. After feeding, high blood glucose and insulin induce lipogenic genes through several pathways, including DNA-PK, aPKC and Akt-mTOR. Various transcription factors and coregulators undergo specific modifications, such as phosphorylation, acetylation, or ubiquitination, which affect their function, stability, or localization. Dysregulation of lipogenesis can contribute to hepatosteatosis, which is associated with obesity and insulin resistance. äTranscriptional Regulation of Hepatic Lipogenesis (epmc).pdf DeepDyve Pubget Overpricing