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10.1007/s12031-016-0732-9 http://scihub22266oqcxt.onion/10.1007/s12031-016-0732-9 C4884566!4884566!26941032     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Neurosci 2016 ; 59 (2): 260-9 Nephropedia Template TP {{tp|p=26941032|t=2016. Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis |pdf=|usr=}}{{26941032}} gab.com Text Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis JO: J Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26941032 #FOAvip Neurogenic inflammation mediated by peptidergic sensory nerves has a crucial impact on the pathogenesis of various joint diseases. Galanin is a regulatory sensory neuropeptide, which has been shown to attenuate neurogenic inflammation, modulate neutrophil activation, and be involved in the development of adjuvant arthritis, but our current understanding about its targets and physiological importance is incomplete. Among the receptors of galanin (GAL1?3), GAL3 has been found to be the most abundantly expressed in the vasculature and on the surface of some immune cells. However, since there are minimal in vivo data on the role of GAL3 in joint diseases, we analyzed its involvement in different inflammatory mechanisms of the K/BxN serum transfer-model of autoimmune arthritis employing GAL3 gene-deficient mice. After arthritis induction, GAL3 knockouts demonstrated increased clinical disease severity and earlier hindlimb edema than wild types. Vascular hyperpermeability determined by in vivo fluorescence imaging was also elevated compared to the wild-type controls. However, neutrophil accumulation detected by in vivo luminescence imaging or arthritic mechanical hyperalgesia was not altered by the lack of the GAL3 receptor. Our findings suggest that GAL3 has anti-inflammatory properties in joints by inhibiting vascular hyperpermeability and consequent edema formation. Twit Text FOAVip Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis ????J Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=26941032 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26941032 #FOAvip English Wikipedia <ref>{{Cite pmid|26941032}}</ref> Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis #MMPMID26941032 Botz B; Kemény Á; Brunner SM; Sternberg F; Csepregi J; Mócsai A; Pintér E; McDougall JJ; Kofler B; Helyes Z J Mol Neurosci 2016[]; 59 (2): 260-9 PMID26941032show ga Neurogenic inflammation mediated by peptidergic sensory nerves has a crucial impact on the pathogenesis of various joint diseases. Galanin is a regulatory sensory neuropeptide, which has been shown to attenuate neurogenic inflammation, modulate neutrophil activation, and be involved in the development of adjuvant arthritis, but our current understanding about its targets and physiological importance is incomplete. Among the receptors of galanin (GAL1?3), GAL3 has been found to be the most abundantly expressed in the vasculature and on the surface of some immune cells. However, since there are minimal in vivo data on the role of GAL3 in joint diseases, we analyzed its involvement in different inflammatory mechanisms of the K/BxN serum transfer-model of autoimmune arthritis employing GAL3 gene-deficient mice. After arthritis induction, GAL3 knockouts demonstrated increased clinical disease severity and earlier hindlimb edema than wild types. Vascular hyperpermeability determined by in vivo fluorescence imaging was also elevated compared to the wild-type controls. However, neutrophil accumulation detected by in vivo luminescence imaging or arthritic mechanical hyperalgesia was not altered by the lack of the GAL3 receptor. Our findings suggest that GAL3 has anti-inflammatory properties in joints by inhibiting vascular hyperpermeability and consequent edema formation. äLack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis (epmc).pdf DeepDyve Pubget Overpricing