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10.1016/j.diff.2015.10.007

http://scihub22266oqcxt.onion/10.1016/j.diff.2015.10.007
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C4884165!4884165!26639079
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suck abstract from ncbi


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pmid26639079      Differentiation 2016 ; 91 (4-5): 4-9
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  • Use of sub-renal capsule transplantation in developmental biology #MMPMID26639079
  • Cunha GR; Baskin L
  • Differentiation 2016[Apr]; 91 (4-5): 4-9 PMID26639079show ga
  • The sub-renal capsule graft site for in vivo growth and development of developing organs and can be Q2 used to great advantage in the ?rescue? of organ rudiments from ?embryonic? or ?birth? lethal mutant mice, which permits examination of the full impact of gene knockout on all phases of development from morphogenesis to adult functional differentiation. Another use of the sub-renal capsule graft site is the examination of normal and ?chemically perturbed? development of human fetal organs. Tissue recombinants composed of various types of epithelium and mesenchyme, when grafted under the renal capsule undergo normal development and in 3?4 weeks achieve full adult functional cytodifferentiation. The investigator can control many of the developmental parameters of the graft such as endocrine status of the host and treatment of the host with a variety of biologically active agents to assess their effects on development and differentiation.
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