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10.1016/j.jvs.2015.11.038 http://scihub22266oqcxt.onion/10.1016/j.jvs.2015.11.038 C4884130!4884130 !26817611     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26817611 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Vasc+Surg 2016 ; 63 (6 ): 1602-1612.e2 Nephropedia Template TP {{tp|p=26817611 |t=2016. Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation |pdf=|usr=}}{{26817611 }} gab.com Text Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation JO: J Vasc Surg http://www.kidney.de/pget.php?&tw=1&pmid=26817611 #FOAvip BACKGROUND: Testosterone is theorized to play a major role in the pathophysiology of abdominal aortic aneurysms (AAAs) because this disease occurs primarily in men. The role of the androgen receptor (AR) in the formation of AAAs has not been well elucidated, and therefore, it is hypothesized that androgen blockade will attenuate experimental aortic aneurysm formation. METHODS: Aortas of 8- to 12-week-old male C57Bl/6 wild-type (WT) mice or male AR knockout (AR(-/-)) mice were perfused with purified porcine pancreatic elastase (0.35 U/mL) to induce AAA formation. Two groups of WT male mice were treated with the AR blockers flutamide (50 mg/kg) or ketoconazole (150 mg/kg) twice daily by intraperitoneal injection. Aortas were harvested on day 14 after video micrometry was used to measure AAA diameter. Cytokine arrays and histologic analysis were performed on aortic tissue. Groups were compared using an analysis of variance and a Tukey post hoc test. RESULTS: Flutamide and ketoconazole treatment (mean ± standard error of the mean) attenuated AAA formation in WT mice (84.2% ± 22.8% [P = .009] and 91.5% ± 18.2% [P = .037]) compared with WT elastase (121% ± 5.23%). In addition, AR(-/-) mice showed attenuation of AAA growth (64.4% ± 22.7%; P < .0001) compared with WT elastase. Cytokine arrays of aortic tissue revealed decreased levels of proinflammatory cytokines interleukin (IL)-?, IL-6, and IL-17 in flutamide-treated and AR(-/-) groups compared with controls. CONCLUSIONS: Pharmacologic and genetic AR blockade cause attenuation of AAA formation. Therapies for AR blockade used in prostate cancer may provide medical treatment to halt progression of AAAs in humans. Twit Text FOAVip Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation ????J Vasc Surg http://www.kidney.de/pget.php?&tw=1&pmid=26817611 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26817611 #FOAvip English Wikipedia <ref>{{Cite pmid|26817611 }}</ref> Pharmacologic blockade and genetic deletion of androgen receptor attenuates aortic aneurysm formation #MMPMID26817611 Davis JP ; Salmon M ; Pope NH ; Lu G ; Su G ; Meher A ; Ailawadi G ; Upchurch GR Jr J Vasc Surg 2016[Jun]; 63 (6 ): 1602-1612.e2 PMID26817611 show ga BACKGROUND: Testosterone is theorized to play a major role in the pathophysiology of abdominal aortic aneurysms (AAAs) because this disease occurs primarily in men. The role of the androgen receptor (AR) in the formation of AAAs has not been well elucidated, and therefore, it is hypothesized that androgen blockade will attenuate experimental aortic aneurysm formation. METHODS: Aortas of 8- to 12-week-old male C57Bl/6 wild-type (WT) mice or male AR knockout (AR(-/-)) mice were perfused with purified porcine pancreatic elastase (0.35 U/mL) to induce AAA formation. Two groups of WT male mice were treated with the AR blockers flutamide (50 mg/kg) or ketoconazole (150 mg/kg) twice daily by intraperitoneal injection. Aortas were harvested on day 14 after video micrometry was used to measure AAA diameter. Cytokine arrays and histologic analysis were performed on aortic tissue. Groups were compared using an analysis of variance and a Tukey post hoc test. RESULTS: Flutamide and ketoconazole treatment (mean ± standard error of the mean) attenuated AAA formation in WT mice (84.2% ± 22.8% [P = .009] and 91.5% ± 18.2% [P = .037]) compared with WT elastase (121% ± 5.23%). In addition, AR(-/-) mice showed attenuation of AAA growth (64.4% ± 22.7%; P < .0001) compared with WT elastase. Cytokine arrays of aortic tissue revealed decreased levels of proinflammatory cytokines interleukin (IL)-?, IL-6, and IL-17 in flutamide-treated and AR(-/-) groups compared with controls. CONCLUSIONS: Pharmacologic and genetic AR blockade cause attenuation of AAA formation. Therapies for AR blockade used in prostate cancer may provide medical treatment to halt progression of AAAs in humans. |*Gene Deletion [MESH] |Androgen Antagonists/*pharmacology [MESH] |Animals [MESH] |Aorta, Abdominal/*drug effects/metabolism/pathology [MESH] |Aortic Aneurysm, Abdominal/chemically induced/genetics/metabolism/*prevention & control [MESH] |Cytokines/metabolism [MESH] |Disease Models, Animal [MESH] |Disease Progression [MESH] |Flutamide/*pharmacology [MESH] |Gene Expression Regulation [MESH] |Genotype [MESH] |Humans [MESH] |Inflammation Mediators/metabolism [MESH] |Ketoconazole/*pharmacology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Pancreatic Elastase [MESH] |Phenotype [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Receptors, Androgen/*deficiency/*drug effects/genetics/metabolism [MESH]Pharmacologic blockade and genetic deletion of androgen receptor atten(epmc).pdf DeepDyve Pubget Overpricing