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10.1681/ASN.2015040468

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suck abstract from ncbi


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pmid26677862
      J+Am+Soc+Nephrol 2016 ; 27 (6 ): 1801-10
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  • Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial #MMPMID26677862
  • Miskulin DC ; Majchrzak K ; Tighiouart H ; Muther RS ; Kapoian T ; Johnson DS ; Weiner DE
  • J Am Soc Nephrol 2016[Jun]; 27 (6 ): 1801-10 PMID26677862 show ga
  • Locally produced 1,25-dihydroxyvitamin D3 may have pleiotropic effects outside of bone. Experimental and observational studies suggest that nutritional vitamin D may enhance erythropoiesis in settings of 25-hydroxy vitamin D (25(OH)D) deficiency. We conducted a double-blind, placebo-controlled, randomized clinical trial to assess the effects of supplementation with ergocalciferol on epoetin utilization and other secondary outcomes in patients on hemodialysis with serum 25(OH)D <30 ng/ml. In all, 276 patients were randomized to 6 months of ergocalciferol or placebo. Mean±SD serum 25(OH)D increased from 16.0±5.9 ng/ml at baseline to 39.2±14.9 ng/ml in the ergocalciferol arm and did not change (16.9±6.4 ng/ml and 17.5±7.4 ng/ml, respectively) in the placebo arm. There was no significant change in epoetin dose over 6 months in the ergocalciferol or placebo arms (geometric mean rate 0.98 [95% confidence interval (95% CI), 0.94 to 1.02] versus 0.99 [95% CI, 0.95 to 1.03], respectively) and no difference across arms (P=0.78). No change occurred in serum calcium, phosphorus, intact parathyroid hormone, or C-reactive protein levels, cinacalcet use, or phosphate binder or calcitriol dose in either study arm. Rates of all-cause, cardiovascular, and infection-related hospitalizations did not differ by study arm, although statistical power was limited for these outcomes. In conclusion, 6 months of supplementation with ergocalciferol increased serum 25(OH)D levels in patients on hemodialysis with vitamin D insufficiency or deficiency, but had no effect on epoetin utilization or secondary biochemical and clinical outcomes.
  • |*Dietary Supplements [MESH]
  • |*Renal Dialysis [MESH]
  • |Double-Blind Method [MESH]
  • |Ergocalciferols/*therapeutic use [MESH]
  • |Humans [MESH]
  • |Middle Aged [MESH]
  • |Vitamin D Deficiency/*drug therapy [MESH]


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