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10.1186/s40169-014-0027-0 http://scihub22266oqcxt.onion/10.1186/s40169-014-0027-0 C4884045!4884045!26932373     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Med 2014 ; 3 (ä): ä Nephropedia Template TP {{tp|p=26932373|t=2014. The hippo signaling pathway: implications for heart regeneration and disease |pdf=|usr=}}{{26932373}} gab.com Text The hippo signaling pathway: implications for heart regeneration and disease JO: Clin Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=26932373 #FOAvip Control of cell number and organ size is critical for appropriate development and tissue homeostasis. Studies in both Drosophila and mammals have established the Hippo signaling pathway as an important modulator of organ size and tumorigenesis. Upon activation, this kinase cascade modulates gene expression through the phosphorylation and inhibition of transcription co-activators that are involved in cell proliferation, differentiation, growth and apoptosis. Hippo signaling serves to limit organ size and suppress malignancies, and has been implicated in tissue regeneration following injury. These outcomes highlight the important role that Hippo signaling plays in regulating both physiologic and pathologic processes. In this review, an overview of the signaling pathway will be discussed as well as recent work that has investigated its role in cardiac development, regeneration and disease.Electronic supplementary material: The online version of this article (doi:10.1186/s40169-014-0027-0) contains supplementary material, which is available to authorized users. Twit Text FOAVip The hippo signaling pathway: implications for heart regeneration and disease ????Clin Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=26932373 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26932373 #FOAvip English Wikipedia <ref>{{Cite pmid|26932373}}</ref> The hippo signaling pathway: implications for heart regeneration and disease #MMPMID26932373 Del Re DP Clin Transl Med 2014[]; 3 (ä): ä PMID26932373show ga Control of cell number and organ size is critical for appropriate development and tissue homeostasis. Studies in both Drosophila and mammals have established the Hippo signaling pathway as an important modulator of organ size and tumorigenesis. Upon activation, this kinase cascade modulates gene expression through the phosphorylation and inhibition of transcription co-activators that are involved in cell proliferation, differentiation, growth and apoptosis. Hippo signaling serves to limit organ size and suppress malignancies, and has been implicated in tissue regeneration following injury. These outcomes highlight the important role that Hippo signaling plays in regulating both physiologic and pathologic processes. In this review, an overview of the signaling pathway will be discussed as well as recent work that has investigated its role in cardiac development, regeneration and disease.Electronic supplementary material: The online version of this article (doi:10.1186/s40169-014-0027-0) contains supplementary material, which is available to authorized users. äThe hippo signaling pathway: implications for heart regeneration and d(epmc).pdf DeepDyve Pubget Overpricing