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10.1139/cjpp-2013-0490 http://scihub22266oqcxt.onion/10.1139/cjpp-2013-0490 C4883005!4883005!24959995     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Can+J+Physiol+Pharmacol 2014 ; 92 (7): 598-604 Nephropedia Template TP {{tp|p=24959995|t=2014. Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts |pdf=|usr=}}{{24959995}} gab.com Text Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts JO: Can J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24959995 #FOAvip Diabetes is an independent risk factor of cardiovascular disease that can eventually cause cardiomyopathy and heart failure. Cardiac fibroblasts (CF) are the critical mediators of physiological and pathological cardiac remodeling, however, the effects of hyperglycemia on cardiac fibroblast function and differentiation is not well known. Here, we performed a comprehensive investigation on the effects of hyperglycemia on cardiac fibroblasts and show that hyperglycemia enhances cardiac fibroblast function and differentiation. We found that high glucose treatment increased collagen I, III and VI gene expression in rat adult cardiac fibroblasts. Interestingly, hyperglycemia increased CF migration and proliferation which is augmented by collagen I and III. Surprisingly, we found that short term hyperglycemia transiently inhibited ERK1/2 activation but increased AKT phosphorylation. Finally, high glucose treatment increased spontaneous differentiation of cardiac fibroblasts to myofibroblasts with increasing passage compared to low glucose. Taken together, these findings suggest that hyperglycemia induces cardiac fibrosis by modulating collagen expression, migration, proliferation and differentiation of cardiac fibroblasts. Twit Text FOAVip Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts ????Can J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24959995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24959995 #FOAvip English Wikipedia <ref>{{Cite pmid|24959995}}</ref> Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts #MMPMID24959995 Shamhart PE; Luther DJ; Adapala RK; Bryant JE; Petersen KA; Meszaros JG; Thodeti CK Can J Physiol Pharmacol 2014[Jul]; 92 (7): 598-604 PMID24959995show ga Diabetes is an independent risk factor of cardiovascular disease that can eventually cause cardiomyopathy and heart failure. Cardiac fibroblasts (CF) are the critical mediators of physiological and pathological cardiac remodeling, however, the effects of hyperglycemia on cardiac fibroblast function and differentiation is not well known. Here, we performed a comprehensive investigation on the effects of hyperglycemia on cardiac fibroblasts and show that hyperglycemia enhances cardiac fibroblast function and differentiation. We found that high glucose treatment increased collagen I, III and VI gene expression in rat adult cardiac fibroblasts. Interestingly, hyperglycemia increased CF migration and proliferation which is augmented by collagen I and III. Surprisingly, we found that short term hyperglycemia transiently inhibited ERK1/2 activation but increased AKT phosphorylation. Finally, high glucose treatment increased spontaneous differentiation of cardiac fibroblasts to myofibroblasts with increasing passage compared to low glucose. Taken together, these findings suggest that hyperglycemia induces cardiac fibrosis by modulating collagen expression, migration, proliferation and differentiation of cardiac fibroblasts. äHyperglycemia enhances function and differentiation of adult rat cardi(epmc).pdf DeepDyve Pubget Overpricing