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2016 ; 16
(ä): 65
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Intravitreal ranibizumab injection combined trabeculectomy versus Ahmed valve
surgery in the treatment of neovascular glaucoma: assessment of efficacy and
complications
#MMPMID27230388
Liu L
; Xu Y
; Huang Z
; Wang X
BMC Ophthalmol
2016[May]; 16
(ä): 65
PMID27230388
show ga
BACKGROUND: Researches have shown anti-vascular endothelial growth factor (VEGF)
agent is effective in treating neovascular eye diseases. The purpose of this
study is to evaluate the efficacy and safety of intravitreal ranibizumab (IVR)
injection combined trabeculectomy in the treatment of neovascular glaucoma (NVG),
and compared it with Ahmed valve surgery. METHODS: Thirty-six NVG patients (37
eyes) from the First Affiliated Hospital of Zhejiang medical college, between
January 1, 2014 and January 31, 2015, were included in this prospective,
interventional clinical study. Eighteen NVG eyes were given IVR injection one
week before trabeculectomy. Ahmed valve implantation surgery was performed in
nineteen eyes. Ocular pain, best corrected visual acuity (BCVA), intraocular
pressure (IOP) and surgical complications were evaluated before and after the
surgery. RESULTS: IOP was significantly decreased following IVR injection
combined trabeculectomy treatment (baseline 57.1?±?8.9 mmHg; week 1,
15.2?±?4.3 mmHg p?=?0.000; month 1, 16.9?±?2.1 mmHg p?=?0.000; month 3,
20.3?±?7.7 mmHg p?=?0.000; month 6, 19.7?±?7.3 mmHg p?=?0.000). There was a
significant, though modest, BCVA improvement in sighted eyes of IVR group
(baseline 2.42?±?0.68, W1 1.80?±?0.91, P?=?0.013; M1 1.77?±?0.93, p?=?0.011). IVR
injection combined trabeculectomy had less postoperative complications and lower
failure ratio than Ahmed surgery (IVR 5.6 %, Ahmed 31.6 %). CONCLUSIONS: The
study revealed that IVR injection combined trabeculectomy was an effective and
safe treatment for NVG. Compared with Ahmed surgery, IVR injection combined
trabeculectomy had less complications and higher success ratio. (Chinese Clinical
Registry, TRN ChiCTR-OPN-16008147, 3/24/2016, retrospectively registered).