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2016 ; 8
(5
): ä Nephropedia Template TP
gab.com Text
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Sesamin Ameliorates High-Fat Diet-Induced Dyslipidemia and Kidney Injury by
Reducing Oxidative Stress
#MMPMID27171111
Zhang R
; Yu Y
; Deng J
; Zhang C
; Zhang J
; Cheng Y
; Luo X
; Han B
; Yang H
Nutrients
2016[May]; 8
(5
): ä PMID27171111
show ga
The study explored the protective effect of sesamin against lipid-induced renal
injury and hyperlipidemia in a rat model. An animal model of hyperlipidemia was
established in Sprague-Dawley rats. Fifty-five adult Sprague-Dawley rats were
divided into five groups. The control group was fed a standard diet, while the
other four groups were fed a high-fat diet for 5 weeks to induce hyperlipidemia.
Three groups received oral sesamin in doses of 40, 80, or 160 mg/(kg·day). Seven
weeks later, the blood lipids, renal function, antioxidant enzyme activities, and
hyperoxide levels in kidney tissues were measured. The renal pathological changes
and expression levels of collagen type IV (Col-IV) and ?-smooth muscle actin
(?-SMA) were analyzed. The administration of sesamin improved the serum total
cholesterol, triglyceride, low-density lipoprotein cholesterol, apolipoprotein-B,
oxidized-low-density lipoprotein, and serum creatinine levels in hyperlipidemic
rats, while it increased the high-density lipoprotein cholesterol and
apolipoprotein-A levels. Sesamin reduced the excretion of 24-h urinary protein
and urinary albumin and downregulated ?-SMA and Col-IV expression. Moreover,
sesamin ameliorated the superoxide dismutase activity and reduced malondialdehyde
levels in kidney tissue. Sesamin could mediate lipid metabolism and ameliorate
renal injury caused by lipid metabolism disorders in a rat model of
hyperlipidemia.