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10.1038/srep26494 http://scihub22266oqcxt.onion/10.1038/srep26494 C4882544!4882544 !27231124     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27231124 &cmd=llinks): Failed to open stream: HTTP request failed! 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ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination |pdf=|usr=}}{{27231124 }} gab.com Text ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27231124 #FOAvip The immune mechanism leading to the generation of protective antibody responses following influenza trivalent inactivated vaccine (TIV) vaccinations remains largely uncharacterized. We recently reported that TIV vaccination induced a transient increase of circulating ICOS(+)PD-1(+)CXCR3(+) T follicular helper (cTfh) cells in blood, which positively correlated with the induction of protective antibody responses measured at day 28. However, whether and how these T cells directly contribute to antibody response remains unclear. In this study, we analyzed the changes after TIV vaccination in the amount and the avidity of the polyclonal antibodies specific for the HA1 subunit of the pandemic H1N1 virus, and analyzed the correlation with the increase of ICOS(+)PD-1(+)CXCR3(+) cTfh cells. We found that both the amount and the avidity of specific antibodies rapidly increased during the first 7 days after TIV. Importantly, the increase of ICOS(+)PD-1(+)CXCR3(+) cTfh cells strongly correlated with the increase in the avidity of antibodies, particularly in subjects who did not have high affinity antibodies at baseline. We propose that ICOS(+)PD-1(+)CXCR3(+) Tfh cells directly contribute to the generation of high-avidity antibodies after TIV vaccinations by selectively interacting with high affinity B cells at extrafollicular sites. Twit Text FOAVip ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27231124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27231124 #FOAvip English Wikipedia <ref>{{Cite pmid|27231124 }}</ref> ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination #MMPMID27231124 Bentebibel SE ; Khurana S ; Schmitt N ; Kurup P ; Mueller C ; Obermoser G ; Palucka AK ; Albrecht RA ; Garcia-Sastre A ; Golding H ; Ueno H Sci Rep 2016[May]; 6 (ä): 26494 PMID27231124 show ga The immune mechanism leading to the generation of protective antibody responses following influenza trivalent inactivated vaccine (TIV) vaccinations remains largely uncharacterized. We recently reported that TIV vaccination induced a transient increase of circulating ICOS(+)PD-1(+)CXCR3(+) T follicular helper (cTfh) cells in blood, which positively correlated with the induction of protective antibody responses measured at day 28. However, whether and how these T cells directly contribute to antibody response remains unclear. In this study, we analyzed the changes after TIV vaccination in the amount and the avidity of the polyclonal antibodies specific for the HA1 subunit of the pandemic H1N1 virus, and analyzed the correlation with the increase of ICOS(+)PD-1(+)CXCR3(+) cTfh cells. We found that both the amount and the avidity of specific antibodies rapidly increased during the first 7 days after TIV. Importantly, the increase of ICOS(+)PD-1(+)CXCR3(+) cTfh cells strongly correlated with the increase in the avidity of antibodies, particularly in subjects who did not have high affinity antibodies at baseline. We propose that ICOS(+)PD-1(+)CXCR3(+) Tfh cells directly contribute to the generation of high-avidity antibodies after TIV vaccinations by selectively interacting with high affinity B cells at extrafollicular sites. |Antibodies, Viral/*blood [MESH] |Antibody Affinity [MESH] |Antibody Specificity [MESH] |Antigens, Viral/immunology [MESH] |B-Lymphocytes/immunology [MESH] |Humans [MESH] |Inducible T-Cell Co-Stimulator Protein/metabolism [MESH] |Influenza A Virus, H1N1 Subtype/*immunology [MESH] |Influenza Vaccines/*immunology [MESH] |Influenza, Human/blood/*immunology/prevention & control [MESH] |Programmed Cell Death 1 Receptor/metabolism [MESH] |Receptors, CXCR3/metabolism [MESH] |T-Lymphocytes, Helper-Inducer/*immunology/metabolism/virology [MESH]ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the gen(epmc).pdf DeepDyve Pubget Overpricing