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10.1038/srep26839 http://scihub22266oqcxt.onion/10.1038/srep26839 C4882503!4882503 !27230788     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27230788 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26839 Nephropedia Template TP {{tp|p=27230788 |t=2016. Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation |pdf=|usr=}}{{27230788 }} gab.com Text Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27230788 #FOAvip CD47-deficient hepatocyte transplantation induces rapid innate immune cell activation and subsequent associated graft loss in syngeneic recipients. However, the role of donor CD47 in regulation of T-cell alloresponses is poorly understood. We addressed this question by assessing OVA-specific immune responses in mice following hepatocyte transplantation from CD47-competent or -deficient OVA-transgenic donors. Compared to sham-operated controls, intrasplenic transplantation of CD47-deficient OVA(+) hepatocytes significantly accelerated rejection of OVA(+) skin grafted 7 days after hepatocyte transplantation. In contrast, mice receiving CD47-competent OVA(+) hepatocytes showed prolonged and even indefinite survival of OVA(+) skin allografts. T cells from mice receiving CD47-deficient, but not CD47-competent, OVA(+) hepatocytes showed significantly enhanced responses to OVA(+) stimulators compared to sham-operated controls. In contrast to the production of tolerogenic cytokines (IL-4 and IL-10) in the recipients of CD47-competent hepatocytes, mice receiving CD47-deficient hepatocytes showed elevated production of IFN-? and IL-1?. Moreover, significant expansion of myeloid-derived suppressor cells was detected in the recipients of CD47-competent hepatocytes, which was required for tolerance induction in these mice. Thus, donor CD47 plays an important role in the control of T-cell alloresponses and tolerance induction following hepatocyte transplantation. Our data also suggest that intrasplenic hepatocyte transplantation may provide a means to induce allograft tolerance. Twit Text FOAVip Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27230788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27230788 #FOAvip English Wikipedia <ref>{{Cite pmid|27230788 }}</ref> Donor CD47 controls T cell alloresponses and is required for tolerance induction following hepatocyte allotransplantation #MMPMID27230788 Zhang M ; Wang H ; Tan S ; Navarro-Alvarez N ; Zheng Y ; Yang YG Sci Rep 2016[May]; 6 (ä): 26839 PMID27230788 show ga CD47-deficient hepatocyte transplantation induces rapid innate immune cell activation and subsequent associated graft loss in syngeneic recipients. However, the role of donor CD47 in regulation of T-cell alloresponses is poorly understood. We addressed this question by assessing OVA-specific immune responses in mice following hepatocyte transplantation from CD47-competent or -deficient OVA-transgenic donors. Compared to sham-operated controls, intrasplenic transplantation of CD47-deficient OVA(+) hepatocytes significantly accelerated rejection of OVA(+) skin grafted 7 days after hepatocyte transplantation. In contrast, mice receiving CD47-competent OVA(+) hepatocytes showed prolonged and even indefinite survival of OVA(+) skin allografts. T cells from mice receiving CD47-deficient, but not CD47-competent, OVA(+) hepatocytes showed significantly enhanced responses to OVA(+) stimulators compared to sham-operated controls. In contrast to the production of tolerogenic cytokines (IL-4 and IL-10) in the recipients of CD47-competent hepatocytes, mice receiving CD47-deficient hepatocytes showed elevated production of IFN-? and IL-1?. Moreover, significant expansion of myeloid-derived suppressor cells was detected in the recipients of CD47-competent hepatocytes, which was required for tolerance induction in these mice. Thus, donor CD47 plays an important role in the control of T-cell alloresponses and tolerance induction following hepatocyte transplantation. Our data also suggest that intrasplenic hepatocyte transplantation may provide a means to induce allograft tolerance. |*Graft Survival [MESH] |*Transplantation Tolerance [MESH] |Animals [MESH] |CD47 Antigen/genetics/*immunology [MESH] |Female [MESH] |Hepatocytes/*immunology/*transplantation [MESH] |Inflammation Mediators/blood [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Myeloid-Derived Suppressor Cells/immunology [MESH] |Skin Transplantation [MESH] |Survival Analysis [MESH]Donor CD47 controls T cell alloresponses and is required for tolerance(epmc).pdf DeepDyve Pubget Overpricing