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10.1111/bph.13493 http://scihub22266oqcxt.onion/10.1111/bph.13493 C4882491!4882491!27059094     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2016 ; 173 (12): 2001-15 Nephropedia Template TP {{tp|p=27059094|t=2016. The role of metformin and resveratrol in the prevention of hypoxia?inducible factor 1? accumulation and fibrosis in hypoxic adipose tissue |pdf=|usr=}}{{27059094}} gab.com Text The role of metformin and resveratrol in the prevention of hypoxia inducible factor 1 accumulation and fibrosis in hypoxic adipose tissue JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27059094 #FOAvip Background and Purpose: Hypoxic activation of hypoxia?inducible factor 1? (HIF?1?) and fibrosis in adipose tissue contribute to adipose dysfunction. This study was designed to investigate the effects of metformin and resveratrol on the regulation of HIF?1? and fibrosis in hypoxic adipose tissue. Experimental Approach: Mice were fed a high?fat diet to induce hypoxia and fibrosis in adipose tissue; adipose tissue incubated in vitro in 1% O2 showed a similar change. The effects of metformin and resveratrol on hypoxia, HIF?1? accumulation, endoplasmic reticulum stress and gene expressions of extracellular matrix components and pro?inflammatory cytokines were examined. Key Results: Oral administration of metformin or resveratrol prevented hypoxia and reduced HIF?1? accumulation with dephosphorylation of inositol?requiring enzyme 1? and eukaryotic initiation factor 2?, indicative of suppression of hypoxic HIF?1? activation and endoplasmic reticulum stress. Metformin and resveratrol down?regulated gene expressions of Col3?, Col6?, elastin and lysyl oxidase and thereby reduced collagen deposition in adipose tissue. The increased gene expressions of TNF??, IL?6, monocyte chemoattractant protein 1 and F4/80 were also down?regulated by metformin and resveratrol. Metformin and resveratrol had similar effects in adipose tissue exposed to 1% O2. Metformin reduced ATP production and prevented the reduction in oxygen tension in 3T3?L1 cells, suggesting that it prevented hypoxia by limiting oxygen consumption, whereas resveratrol reduced HIF?1? accumulation by promoting its proteasomal degradation via the regulation of AMPK/SIRT1. Conclusion and Implications: Hypoxia and fibrosis are early causes of adipose dysfunction in obesity. Both metformin and resveratrol effectively inhibited HIF?1? activation?induced fibrosis and inflammation in adipose tissue, although by different mechanisms. Twit Text FOAVip The role of metformin and resveratrol in the prevention of hypoxia inducible factor 1 accumulation and fibrosis in hypoxic adipose tissue ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27059094 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27059094 #FOAvip English Wikipedia <ref>{{Cite pmid|27059094}}</ref> The role of metformin and resveratrol in the prevention of hypoxia?inducible factor 1? accumulation and fibrosis in hypoxic adipose tissue #MMPMID27059094 Li X; Li J; Wang L; Li A; Qiu Z; Qi L; Kou J; Liu K; Liu B; Huang F Br J Pharmacol 2016[Jun]; 173 (12): 2001-15 PMID27059094show ga Background and Purpose: Hypoxic activation of hypoxia?inducible factor 1? (HIF?1?) and fibrosis in adipose tissue contribute to adipose dysfunction. This study was designed to investigate the effects of metformin and resveratrol on the regulation of HIF?1? and fibrosis in hypoxic adipose tissue. Experimental Approach: Mice were fed a high?fat diet to induce hypoxia and fibrosis in adipose tissue; adipose tissue incubated in vitro in 1% O2 showed a similar change. The effects of metformin and resveratrol on hypoxia, HIF?1? accumulation, endoplasmic reticulum stress and gene expressions of extracellular matrix components and pro?inflammatory cytokines were examined. Key Results: Oral administration of metformin or resveratrol prevented hypoxia and reduced HIF?1? accumulation with dephosphorylation of inositol?requiring enzyme 1? and eukaryotic initiation factor 2?, indicative of suppression of hypoxic HIF?1? activation and endoplasmic reticulum stress. Metformin and resveratrol down?regulated gene expressions of Col3?, Col6?, elastin and lysyl oxidase and thereby reduced collagen deposition in adipose tissue. The increased gene expressions of TNF??, IL?6, monocyte chemoattractant protein 1 and F4/80 were also down?regulated by metformin and resveratrol. Metformin and resveratrol had similar effects in adipose tissue exposed to 1% O2. Metformin reduced ATP production and prevented the reduction in oxygen tension in 3T3?L1 cells, suggesting that it prevented hypoxia by limiting oxygen consumption, whereas resveratrol reduced HIF?1? accumulation by promoting its proteasomal degradation via the regulation of AMPK/SIRT1. Conclusion and Implications: Hypoxia and fibrosis are early causes of adipose dysfunction in obesity. Both metformin and resveratrol effectively inhibited HIF?1? activation?induced fibrosis and inflammation in adipose tissue, although by different mechanisms. äThe role of metformin and resveratrol in the prevention of hypoxia?ind(epmc).pdf DeepDyve Pubget Overpricing