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2016 ; 4
(ä): 47-57
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English Wikipedia
How to Grow a Lung: Applying Principles of Developmental Biology to Generate Lung
Lineages from Human Pluripotent Stem Cells
#MMPMID27340610
Dye BR
; Miller AJ
; Spence JR
Curr Pathobiol Rep
2016[]; 4
(ä): 47-57
PMID27340610
show ga
The number and severity of diseases affecting human lung development and adult
respiratory function has stimulated great interest in new in vitro models to
study the human lung. This review summarizes the most recent breakthroughs
deriving lung lineages in a dish by directing the differentiation of human
pluripotent stem cells. A variety of culturing platforms have been developed,
including two-dimensional and three-dimensional (organoid) culture platforms, to
derive specific cell types and structures of the lung. These stem cell-derived
lung models will further our understanding of human lung development, disease,
and regeneration.