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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Intensive+Care
2016 ; 6
(1
): 48
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gab.com Text
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English Wikipedia
Acute kidney injury in the perioperative period and in intensive care units
(excluding renal replacement therapies)
#MMPMID27230984
Ichai C
; Vinsonneau C
; Souweine B
; Armando F
; Canet E
; Clec'h C
; Constantin JM
; Darmon M
; Duranteau J
; Gaillot T
; Garnier A
; Jacob L
; Joannes-Boyau O
; Juillard L
; Journois D
; Lautrette A
; Muller L
; Legrand M
; Lerolle N
; Rimmelé T
; Rondeau E
; Tamion F
; Walrave Y
; Velly L
Ann Intensive Care
2016[Dec]; 6
(1
): 48
PMID27230984
show ga
Acute kidney injury (AKI) is a syndrome that has progressed a great deal over the
last 20 years. The decrease in urine output and the increase in classical renal
biomarkers, such as blood urea nitrogen and serum creatinine, have largely been
used as surrogate markers for decreased glomerular filtration rate (GFR), which
defines AKI. However, using such markers of GFR as criteria for diagnosing AKI
has several limits including the difficult diagnosis of non-organic AKI, also
called "functional renal insufficiency" or "pre-renal insufficiency". This
situation is characterized by an oliguria and an increase in creatininemia as a
consequence of a reduction in renal blood flow related to systemic haemodynamic
abnormalities. In this situation, "renal insufficiency" seems rather
inappropriate as kidney function is not impaired. On the contrary, the kidney
delivers an appropriate response aiming to recover optimal systemic physiological
haemodynamic conditions. Considering the kidney as insufficient is erroneous
because this suggests that it does not work correctly, whereas the opposite is
occurring, because the kidney is healthy even in a threatening situation. With
current definitions of AKI, normalization of volaemia is needed before defining
AKI in order to avoid this pitfall.