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10.1097/SLA.0000000000001364 http://scihub22266oqcxt.onion/10.1097/SLA.0000000000001364 C4882269!4882269!26649588     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Surg 2016 ; 264 (1): 169-79 Nephropedia Template TP {{tp|p=26649588|t=2016. THE HUMAN PANCREAS AS A SOURCE OF PRO-TOLEROGENIC EXTRACELLULAR MATRIX SCAFFOLD FOR A NEW GENERATION BIO-ARTIFICIAL ENDOCRINE PANCREAS |pdf=|usr=}}{{26649588}} gab.com Text THE HUMAN PANCREAS AS A SOURCE OF PRO-TOLEROGENIC EXTRACELLULAR MATRIX SCAFFOLD FOR A NEW GENERATION BIO-ARTIFICIAL ENDOCRINE PANCREAS JO: Ann Surg http://www.kidney.de/pget.php?&tw=1&pmid=26649588 #FOAvip OBJECTIVE: Our study aims at producing acellular extracellular matrix scaffolds from the human pancreas (hpaECMs), as a first critical step towards the production of a new generation, fully human-derived bio-artificial endocrine pancreas (BAEP). In this BAEP, the hardware will be represented by hpaECMs, while the software will consist in the cellular compartment generated from patient?s own cells. SUMMARY BACKGROUND DATA: ECM-based scaffolds obtained through the decellularization of native organs have become the favored platform in the field of complex organ bioengineering. However, the paradigm is now switching from the porcine to the human model. METHODS: To achieve our goal, human pancreata were decellularized with Triton-based solution and thoroughly characterized. Primary endpoints were: complete cell and DNA clearance, preservation of ECM components, growth factors (GFs) and stiffness, ability to induce angiogenesis, conservation of the framework of the innate vasculature, and immunogenicity. Secondary endpoint was hpaECMs? ability to sustain growth and function of human islet and human primary pancreatic endothelial cells (hPPEC). RESULTS: Results show that hpaECMs can be successfully and consistently produced from human pancreata, maintain their innate molecular and spatial framework and stiffness, as well as vital GFs. Importantly, hpaECMs inhibit human naïve CD4+ T cell expansion in response to polyclonal stimuli by inducing their apoptosis and promoting their conversion into regulatory T cells. hpaECMs are cytocompatible and supportive of representative pancreatic cell types. DISCUSSION: We therefore conclude that hpaECMs has the potential to become an ideal platform for investigations aiming at the manufacturing of a regenerative medicine-inspired BAEP. Twit Text FOAVip THE HUMAN PANCREAS AS A SOURCE OF PRO-TOLEROGENIC EXTRACELLULAR MATRIX SCAFFOLD FOR A NEW GENERATION BIO-ARTIFICIAL ENDOCRINE PANCREAS ????Ann Surg http://www.kidney.de/pget.php?&tw=1&pmid=26649588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26649588 #FOAvip English Wikipedia <ref>{{Cite pmid|26649588}}</ref> THE HUMAN PANCREAS AS A SOURCE OF PRO-TOLEROGENIC EXTRACELLULAR MATRIX SCAFFOLD FOR A NEW GENERATION BIO-ARTIFICIAL ENDOCRINE PANCREAS #MMPMID26649588 Peloso A; Urbani L; Cravedi P; Katari R; Maghsoudlou P; Alvarez Fallas ME; Sordi V; Citro A; Purroy C; Niu G; McQuilling JP; Sittadjody S; Farney AC; Iskandar SS; Rogers J; Stratta RJ; Opara EC; Piemonti L; Furdui C; Soker S; De Coppi P; Orlando G Ann Surg 2016[Jul]; 264 (1): 169-79 PMID26649588show ga OBJECTIVE: Our study aims at producing acellular extracellular matrix scaffolds from the human pancreas (hpaECMs), as a first critical step towards the production of a new generation, fully human-derived bio-artificial endocrine pancreas (BAEP). In this BAEP, the hardware will be represented by hpaECMs, while the software will consist in the cellular compartment generated from patient?s own cells. SUMMARY BACKGROUND DATA: ECM-based scaffolds obtained through the decellularization of native organs have become the favored platform in the field of complex organ bioengineering. However, the paradigm is now switching from the porcine to the human model. METHODS: To achieve our goal, human pancreata were decellularized with Triton-based solution and thoroughly characterized. Primary endpoints were: complete cell and DNA clearance, preservation of ECM components, growth factors (GFs) and stiffness, ability to induce angiogenesis, conservation of the framework of the innate vasculature, and immunogenicity. Secondary endpoint was hpaECMs? ability to sustain growth and function of human islet and human primary pancreatic endothelial cells (hPPEC). RESULTS: Results show that hpaECMs can be successfully and consistently produced from human pancreata, maintain their innate molecular and spatial framework and stiffness, as well as vital GFs. Importantly, hpaECMs inhibit human naïve CD4+ T cell expansion in response to polyclonal stimuli by inducing their apoptosis and promoting their conversion into regulatory T cells. hpaECMs are cytocompatible and supportive of representative pancreatic cell types. DISCUSSION: We therefore conclude that hpaECMs has the potential to become an ideal platform for investigations aiming at the manufacturing of a regenerative medicine-inspired BAEP. äTHE HUMAN PANCREAS AS A SOURCE OF PRO-TOLEROGENIC EXTRACELLULAR MATRIX(epmc).pdf DeepDyve Pubget Overpricing