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10.1038/300611a0 http://scihub22266oqcxt.onion/10.1038/300611a0 C4881848!4881848 !6958982     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=6958982 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\6958982 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nature 1982 ; 300 (5893 ): 611-5 Nephropedia Template TP {{tp|p=6958982 |t=1982. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes |pdf=|usr=}}{{6958982 }} gab.com Text Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=6958982 #FOAvip A DNA fragment containing the promoter of the mouse metallothionein-I gene fused to the structural gene of rat growth hormone was microinjected into the pronuclei of fertilized mouse eggs. Of 21 mice that developed from these eggs, seven carried the fusion gene and six of these grew significantly larger than their littermates. Several of these transgenic mice had extraordinarily high levels of the fusion mRNA in their liver and growth hormone in their serum. This approach has implications for studying the biological effects of growth hormone, as a way to accelerate animal growth, as a model for gigantism, as a means of correcting genetic disease, and as a method of farming valuable gene products. Twit Text FOAVip Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=6958982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=6958982 #FOAvip English Wikipedia <ref>{{Cite pmid|6958982 }}</ref> Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes #MMPMID6958982 Palmiter RD ; Brinster RL ; Hammer RE ; Trumbauer ME ; Rosenfeld MG ; Birnberg NC ; Evans RM Nature 1982[Dec]; 300 (5893 ): 611-5 PMID6958982 show ga A DNA fragment containing the promoter of the mouse metallothionein-I gene fused to the structural gene of rat growth hormone was microinjected into the pronuclei of fertilized mouse eggs. Of 21 mice that developed from these eggs, seven carried the fusion gene and six of these grew significantly larger than their littermates. Several of these transgenic mice had extraordinarily high levels of the fusion mRNA in their liver and growth hormone in their serum. This approach has implications for studying the biological effects of growth hormone, as a way to accelerate animal growth, as a model for gigantism, as a means of correcting genetic disease, and as a method of farming valuable gene products. |*Genetic Engineering [MESH] |Animals [MESH] |Gene Expression Regulation [MESH] |Growth Hormone/blood/*genetics [MESH] |Liver/physiology [MESH] |Metalloproteins/*genetics [MESH] |Metallothionein/*genetics [MESH] |Mice/*growth & development [MESH]Dramatic growth of mice that develop from eggs microinjected with me(epmc).pdf DeepDyve Pubget Overpricing