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10.3390/ijms17050751 http://scihub22266oqcxt.onion/10.3390/ijms17050751 C4881572!4881572!27213332     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2016 ; 17 (5): ä Nephropedia Template TP {{tp|p=27213332|t=2016. Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis |pdf=|usr=}}{{27213332}} gab.com Text Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27213332 #FOAvip Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions. The present study determined the ability of the most abundant EDP regioisomer, 19,20-EDP to reduce kidney injury in an experimental unilateral ureteral obstruction (UUO) renal fibrosis mouse model. Mice with UUO developed kidney tubular injury and interstitial fibrosis. UUO mice had elevated kidney hydroxyproline content and five-times greater collagen positive fibrotic area than sham control mice. 19,20-EDP treatment to UUO mice for 10 days reduced renal fibrosis with a 40%?50% reduction in collagen positive area and hydroxyproline content. There was a six-fold increase in kidney ?-smooth muscle actin (?-SMA) positive area in UUO mice compared to sham control mice, and 19,20-EDP treatment to UUO mice decreased ?-SMA immunopositive area by 60%. UUO mice demonstrated renal epithelial-to-mesenchymal transition (EMT) with reduced expression of the epithelial marker E-cadherin and elevated expression of multiple mesenchymal markers (FSP-1, ?-SMA, and desmin). Interestingly, 19,20-EDP treatment reduced renal EMT in UUO by decreasing mesenchymal and increasing epithelial marker expression. Overall, we demonstrate that a novel omega-3 fatty acid metabolite 19,20-EDP, prevents UUO-induced renal fibrosis in mice by reducing renal EMT. Twit Text FOAVip Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27213332 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27213332 #FOAvip English Wikipedia <ref>{{Cite pmid|27213332}}</ref> Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis #MMPMID27213332 Sharma A; Khan MAH; Levick SP; Lee KSS; Hammock BD; Imig JD Int J Mol Sci 2016[May]; 17 (5): ä PMID27213332show ga Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions. The present study determined the ability of the most abundant EDP regioisomer, 19,20-EDP to reduce kidney injury in an experimental unilateral ureteral obstruction (UUO) renal fibrosis mouse model. Mice with UUO developed kidney tubular injury and interstitial fibrosis. UUO mice had elevated kidney hydroxyproline content and five-times greater collagen positive fibrotic area than sham control mice. 19,20-EDP treatment to UUO mice for 10 days reduced renal fibrosis with a 40%?50% reduction in collagen positive area and hydroxyproline content. There was a six-fold increase in kidney ?-smooth muscle actin (?-SMA) positive area in UUO mice compared to sham control mice, and 19,20-EDP treatment to UUO mice decreased ?-SMA immunopositive area by 60%. UUO mice demonstrated renal epithelial-to-mesenchymal transition (EMT) with reduced expression of the epithelial marker E-cadherin and elevated expression of multiple mesenchymal markers (FSP-1, ?-SMA, and desmin). Interestingly, 19,20-EDP treatment reduced renal EMT in UUO by decreasing mesenchymal and increasing epithelial marker expression. Overall, we demonstrate that a novel omega-3 fatty acid metabolite 19,20-EDP, prevents UUO-induced renal fibrosis in mice by reducing renal EMT. äNovel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosi(epmc).pdf DeepDyve Pubget Overpricing