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10.3390/ijms17050735 http://scihub22266oqcxt.onion/10.3390/ijms17050735 C4881557!4881557!27187382     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27187382&cmd=llinks): Failed to open stream: HTTP request failed! 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Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects |pdf=|usr=}}{{27187382}} gab.com Text Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27187382 #FOAvip Sirolimus (SRL) and everolimus (EVR) are mammalian targets of rapamycin inhibitors (mTOR-I) largely employed in renal transplantation and oncology as immunosuppressive/antiproliferative agents. SRL was the first mTOR-I produced by the bacterium Streptomyces hygroscopicus and approved for several medical purposes. EVR, derived from SRL, contains a 2-hydroxy-ethyl chain in the 40th position that makes the drug more hydrophilic than SRL and increases oral bioavailability. Their main mechanism of action is the inhibition of the mTOR complex 1 and the regulation of factors involved in a several crucial cellular functions including: protein synthesis, regulation of angiogenesis, lipid biosynthesis, mitochondrial biogenesis and function, cell cycle, and autophagy. Most of the proteins/enzymes belonging to the aforementioned biological processes are encoded by numerous and tightly regulated genes. However, at the moment, the polygenic influence on SRL/EVR cellular effects is still not completely defined, and its comprehension represents a key challenge for researchers. Therefore, to obtain a complete picture of the cellular network connected to SRL/EVR, we decided to review major evidences available in the literature regarding the genetic influence on mTOR-I biology/pharmacology and to build, for the first time, a useful and specific ?SRL/EVR genes-focused pathway?, possibly employable as a starting point for future in-depth research projects. Twit Text FOAVip Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27187382 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27187382 #FOAvip English Wikipedia <ref>{{Cite pmid|27187382}}</ref> Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects #MMPMID27187382 Granata S; Dalla Gassa A; Carraro A; Brunelli M; Stallone G; Lupo A; Zaza G Int J Mol Sci 2016[May]; 17 (5): ä PMID27187382show ga Sirolimus (SRL) and everolimus (EVR) are mammalian targets of rapamycin inhibitors (mTOR-I) largely employed in renal transplantation and oncology as immunosuppressive/antiproliferative agents. SRL was the first mTOR-I produced by the bacterium Streptomyces hygroscopicus and approved for several medical purposes. EVR, derived from SRL, contains a 2-hydroxy-ethyl chain in the 40th position that makes the drug more hydrophilic than SRL and increases oral bioavailability. Their main mechanism of action is the inhibition of the mTOR complex 1 and the regulation of factors involved in a several crucial cellular functions including: protein synthesis, regulation of angiogenesis, lipid biosynthesis, mitochondrial biogenesis and function, cell cycle, and autophagy. Most of the proteins/enzymes belonging to the aforementioned biological processes are encoded by numerous and tightly regulated genes. However, at the moment, the polygenic influence on SRL/EVR cellular effects is still not completely defined, and its comprehension represents a key challenge for researchers. Therefore, to obtain a complete picture of the cellular network connected to SRL/EVR, we decided to review major evidences available in the literature regarding the genetic influence on mTOR-I biology/pharmacology and to build, for the first time, a useful and specific ?SRL/EVR genes-focused pathway?, possibly employable as a starting point for future in-depth research projects. äSirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencin(epmc).pdf DeepDyve Pubget Overpricing