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10.3390/ijms17050729 http://scihub22266oqcxt.onion/10.3390/ijms17050729 C4881551!4881551!27187375     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2016 ; 17 (5): ä Nephropedia Template TP {{tp|p=27187375|t=2016. The Use of 1?,25-Dihydroxyvitamin D3 as an Anticancer Agent |pdf=|usr=}}{{27187375}} gab.com Text The Use of 1 ,25-Dihydroxyvitamin D3 as an Anticancer Agent JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27187375 #FOAvip The notion that vitamin D can influence the incidence of cancer arose from epidemiological studies. The major source of vitamin D in the organism is skin production upon exposure to ultra violet-B. The very first observation of an inverse correlation between exposure of individuals to the sun and the likelihood of cancer was reported as early as 1941. In 1980, Garland and Garland hypothesised, from findings from epidemiological studies of patients in the US with colon cancer, that vitamin D produced in response to sun exposure is protective against cancer as opposed to sunlight per se. Later studies revealed inverse correlations between sun exposure and the occurrence of prostate and breast cancers. These observations prompted laboratory investigation of whether or not vitamin D had an effect on cancer cells. Vitamin D is not active against cancer cells, but the most active metabolite 1?,25-dihydroxyvitamin D3 (1,25D) has profound biological effects. Here, we review the anticancer action of 1,25D, clinical trials of 1,25D to date and the prospects of the future therapeutic use of new and low calcaemic analogues. Twit Text FOAVip The Use of 1 ,25-Dihydroxyvitamin D3 as an Anticancer Agent ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27187375 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27187375 #FOAvip English Wikipedia <ref>{{Cite pmid|27187375}}</ref> The Use of 1?,25-Dihydroxyvitamin D3 as an Anticancer Agent #MMPMID27187375 Marcinkowska E; Wallace GR; Brown G Int J Mol Sci 2016[May]; 17 (5): ä PMID27187375show ga The notion that vitamin D can influence the incidence of cancer arose from epidemiological studies. The major source of vitamin D in the organism is skin production upon exposure to ultra violet-B. The very first observation of an inverse correlation between exposure of individuals to the sun and the likelihood of cancer was reported as early as 1941. In 1980, Garland and Garland hypothesised, from findings from epidemiological studies of patients in the US with colon cancer, that vitamin D produced in response to sun exposure is protective against cancer as opposed to sunlight per se. Later studies revealed inverse correlations between sun exposure and the occurrence of prostate and breast cancers. These observations prompted laboratory investigation of whether or not vitamin D had an effect on cancer cells. Vitamin D is not active against cancer cells, but the most active metabolite 1?,25-dihydroxyvitamin D3 (1,25D) has profound biological effects. Here, we review the anticancer action of 1,25D, clinical trials of 1,25D to date and the prospects of the future therapeutic use of new and low calcaemic analogues. äThe Use of 1?,25-Dihydroxyvitamin D3 as an Anticancer Agent (epmc).pdf DeepDyve Pubget Overpricing