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2016 ; 17
(5
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
New Is Old, and Old Is New: Recent Advances in Antibiotic-Based, Antibiotic-Free
and Ethnomedical Treatments against Methicillin-Resistant Staphylococcus aureus
Wound Infections
#MMPMID27120596
Dou JL
; Jiang YW
; Xie JQ
; Zhang XG
Int J Mol Sci
2016[Apr]; 17
(5
): ä PMID27120596
show ga
Staphylococcus aureus is the most common pathogen of wound infections. Thus far,
methicillin-resistant S. aureus (MRSA) has become the major causative agent in
wound infections, especially for nosocomial infections. MRSA infections are
seldom eradicated by routine antimicrobial therapies. More concerning, some
strains have become resistant to the newest antibiotics of last resort.
Furthermore, horizontal transfer of a polymyxin resistance gene, mcr-1, has been
identified in Enterobacteriaceae, by which resistance to the last group of
antibiotics will likely spread rapidly. The worst-case scenario, "a return to the
pre-antibiotic era", is likely in sight. A perpetual goal for antibiotic research
is the discovery of an antibiotic that lacks resistance potential, such as the
recent discovery of teixobactin. However, when considering the issue from an
ecological and evolutionary standpoint, it is evident that it is insufficient to
solve the antibiotic dilemma through the use of antibiotics themselves. In this
review, we summarized recent advances in antibiotic-based, antibiotic-free and
ethnomedical treatments against MRSA wound infections to identify new clues to
solve the antibiotic dilemma. One potential solution is to use ethnomedical drugs
topically. Some ethnomedical drugs have been demonstrated to be effective
antimicrobials against MRSA. A decline in antibiotic resistance can therefore be
expected, as has been demonstrated when antibiotic-free treatments were used to
limit the use of antibiotics. It is also anticipated that these drugs will have
low resistance potential, although there is only minimal evidence to support this
claim to date. More clinical trials and animal tests should be conducted on this
topic.