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10.3390/ijms17050598 http://scihub22266oqcxt.onion/10.3390/ijms17050598 C4881437!4881437!27136531     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2016 ; 17 (5): ä Nephropedia Template TP {{tp|p=27136531|t=2016. Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse |pdf=|usr=}}{{27136531}} gab.com Text Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27136531 #FOAvip Colorectal cancer (CRC) is one of the leading causes of cancer mortality. Metastasis remains the primary cause of CRC death. Predicting the possibility of metastatic relapse in early-stage CRC is of paramount importance to target therapy for patients who really need it and spare those with low-potential of metastasis. Ninety-six stage II CRC cases were stratified using high-resolution array comparative genomic hybridization (aCGH) data based on a predictive survival algorithm and supervised clustering. All genes included within the resultant copy number aberrations were each interrogated independently at mRNA level using CRC expression datasets available from public repositories, which included 1820 colon cancers, and 167 normal colon tissues. Reduced mRNA expression driven by copy number losses and increased expression driven by copy number gains revealed 42 altered transcripts (29 reduced and 13 increased transcripts) associated with metastatic relapse, short disease-free or overall survival, and/or epithelial to mesenchymal transition (EMT). Resultant genes were classified based on gene ontology (GO), which identified four functional enrichment groups involved in growth regulation, genomic integrity, metabolism, and signal transduction pathways. The identified 42 genes may be useful for predicting metastatic relapse in stage II CRC. Further studies are necessary to validate these findings. Twit Text FOAVip Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27136531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27136531 #FOAvip English Wikipedia <ref>{{Cite pmid|27136531}}</ref> Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse #MMPMID27136531 Al-Temaimi RA; Tan TZ; Marafie MJ; Thiery JP; Quirke P; Al-Mulla F Int J Mol Sci 2016[May]; 17 (5): ä PMID27136531show ga Colorectal cancer (CRC) is one of the leading causes of cancer mortality. Metastasis remains the primary cause of CRC death. Predicting the possibility of metastatic relapse in early-stage CRC is of paramount importance to target therapy for patients who really need it and spare those with low-potential of metastasis. Ninety-six stage II CRC cases were stratified using high-resolution array comparative genomic hybridization (aCGH) data based on a predictive survival algorithm and supervised clustering. All genes included within the resultant copy number aberrations were each interrogated independently at mRNA level using CRC expression datasets available from public repositories, which included 1820 colon cancers, and 167 normal colon tissues. Reduced mRNA expression driven by copy number losses and increased expression driven by copy number gains revealed 42 altered transcripts (29 reduced and 13 increased transcripts) associated with metastatic relapse, short disease-free or overall survival, and/or epithelial to mesenchymal transition (EMT). Resultant genes were classified based on gene ontology (GO), which identified four functional enrichment groups involved in growth regulation, genomic integrity, metabolism, and signal transduction pathways. The identified 42 genes may be useful for predicting metastatic relapse in stage II CRC. Further studies are necessary to validate these findings. äIdentification of 42 Genes Linked to Stage II Colorectal Cancer Metast(epmc).pdf DeepDyve Pubget Overpricing