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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Oncol
2015 ; 33
(6
): 654-6
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Venous thromboembolism prophylaxis and treatment in patients with cancer:
american society of clinical oncology clinical practice guideline update 2014
#MMPMID25605844
Lyman GH
; Bohlke K
; Khorana AA
; Kuderer NM
; Lee AY
; Arcelus JI
; Balaban EP
; Clarke JM
; Flowers CR
; Francis CW
; Gates LE
; Kakkar AK
; Key NS
; Levine MN
; Liebman HA
; Tempero MA
; Wong SL
; Somerfield MR
; Falanga A
J Clin Oncol
2015[Feb]; 33
(6
): 654-6
PMID25605844
show ga
PURPOSE: To provide current recommendations about the prophylaxis and treatment
of venous thromboembolism (VTE) in patients with cancer. METHODS: PubMed and the
Cochrane Library were searched for randomized controlled trials, systematic
reviews, meta-analyses, and clinical practice guidelines from November 2012
through July 2014. An update committee reviewed the identified abstracts.
RESULTS: Of the 53 publications identified and reviewed, none prompted a change
in the 2013 recommendations. RECOMMENDATIONS: Most hospitalized patients with
active cancer require thromboprophylaxis throughout hospitalization. Routine
thromboprophylaxis is not recommended for patients with cancer in the outpatient
setting. It may be considered for selected high-risk patients. Patients with
multiple myeloma receiving antiangiogenesis agents with chemotherapy and/or
dexamethasone should receive prophylaxis with either low-molecular weight heparin
(LMWH) or low-dose aspirin. Patients undergoing major surgery should receive
prophylaxis starting before surgery and continuing for at least 7 to 10 days.
Extending prophylaxis up to 4 weeks should be considered in those undergoing
major abdominal or pelvic surgery with high-risk features. LMWH is recommended
for the initial 5 to 10 days of treatment for deep vein thrombosis and pulmonary
embolism as well as for long-term secondary prophylaxis (at least 6 months). Use
of novel oral anticoagulants is not currently recommended for patients with
malignancy and VTE because of limited data in patients with cancer.
Anticoagulation should not be used to extend survival of patients with cancer in
the absence of other indications. Patients with cancer should be periodically
assessed for VTE risk. Oncology professionals should educate patients about the
signs and symptoms of VTE.