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10.1038/srep26683 http://scihub22266oqcxt.onion/10.1038/srep26683 C4881239!4881239 !27226084     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27226084 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27226084 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 26683 Nephropedia Template TP {{tp|p=27226084 |t=2016. Controlled Release of Collagen-Binding SDF-1? Improves Cardiac Function after Myocardial Infarction by Recruiting Endogenous Stem Cells |pdf=|usr=}}{{27226084 }} gab.com Text Controlled Release of Collagen-Binding SDF-1 Improves Cardiac Function after Myocardial Infarction by Recruiting Endogenous Stem Cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27226084 #FOAvip Stromal cell-derived factor-1? (SDF-1?) is a well-characterized chemokine that mobilizes stem cells homing to the ischemic heart, which is beneficial for cardiac regeneration. However, clinically administered native SDF-1? diffuses quickly, thus decreasing its local concentration, and results in side effects. Thus, a controlled release system for SDF-1? is required to produce an effective local concentration in the ischemic heart. In this study, we developed a recombinant chemokine, consisting of SDF-1? and a collagen-binding domain, which retains both the SDF-1? and collagen-binding activity (CBD-SDF-1?). In an in vitro assay, CBD-SDF-1? could specifically bind to a collagen gel and achieve sustained release. An intramyocardial injection of CBD-SDF-1? after acute myocardial infarction demonstrated that the protein was largely tethered in the ischemic area and that controlled release had been achieved. Furthermore, CBD-SDF-1? enhanced the recruitment of c-kit positive (c-kit(+)) stem cells, increased capillary density and improved cardiac function, whereas NAT-SDF-1? had no such beneficial effects. Our findings demonstrate that CBD-SDF-1? can specifically bind to collagen and achieve controlled release both in vitro and in vivo. Local delivery of this protein could mobilize endogenous stem cells homing to the ischemic heart and improve cardiac function after myocardial infarction. Twit Text FOAVip Controlled Release of Collagen-Binding SDF-1 Improves Cardiac Function after Myocardial Infarction by Recruiting Endogenous Stem Cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27226084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27226084 #FOAvip English Wikipedia <ref>{{Cite pmid|27226084 }}</ref> Controlled Release of Collagen-Binding SDF-1? Improves Cardiac Function after Myocardial Infarction by Recruiting Endogenous Stem Cells #MMPMID27226084 Sun J ; Zhao Y ; Li Q ; Chen B ; Hou X ; Xiao Z ; Dai J Sci Rep 2016[May]; 6 (ä): 26683 PMID27226084 show ga Stromal cell-derived factor-1? (SDF-1?) is a well-characterized chemokine that mobilizes stem cells homing to the ischemic heart, which is beneficial for cardiac regeneration. However, clinically administered native SDF-1? diffuses quickly, thus decreasing its local concentration, and results in side effects. Thus, a controlled release system for SDF-1? is required to produce an effective local concentration in the ischemic heart. In this study, we developed a recombinant chemokine, consisting of SDF-1? and a collagen-binding domain, which retains both the SDF-1? and collagen-binding activity (CBD-SDF-1?). In an in vitro assay, CBD-SDF-1? could specifically bind to a collagen gel and achieve sustained release. An intramyocardial injection of CBD-SDF-1? after acute myocardial infarction demonstrated that the protein was largely tethered in the ischemic area and that controlled release had been achieved. Furthermore, CBD-SDF-1? enhanced the recruitment of c-kit positive (c-kit(+)) stem cells, increased capillary density and improved cardiac function, whereas NAT-SDF-1? had no such beneficial effects. Our findings demonstrate that CBD-SDF-1? can specifically bind to collagen and achieve controlled release both in vitro and in vivo. Local delivery of this protein could mobilize endogenous stem cells homing to the ischemic heart and improve cardiac function after myocardial infarction. |*Chemokine CXCL12/pharmacokinetics/pharmacology [MESH] |*Collagen/pharmacokinetics/pharmacology [MESH] |*Myocardial Infarction/drug therapy/metabolism/pathology [MESH] |Animals [MESH] |Delayed-Action Preparations/pharmacokinetics/pharmacology [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Myocardium/*metabolism/pathology [MESH] |Recovery of Function/*drug effects [MESH]Controlled Release of Collagen-Binding SDF-1? Improves Cardiac Functio(epmc).pdf DeepDyve Pubget Overpricing