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10.1186/s13059-016-0969-1

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suck abstract from ncbi


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pmid27224977
      Genome+Biol 2016 ; 17 (1 ): 111
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  • Taxonomer: an interactive metagenomics analysis portal for universal pathogen detection and host mRNA expression profiling #MMPMID27224977
  • Flygare S ; Simmon K ; Miller C ; Qiao Y ; Kennedy B ; Di Sera T ; Graf EH ; Tardif KD ; Kapusta A ; Rynearson S ; Stockmann C ; Queen K ; Tong S ; Voelkerding KV ; Blaschke A ; Byington CL ; Jain S ; Pavia A ; Ampofo K ; Eilbeck K ; Marth G ; Yandell M ; Schlaberg R
  • Genome Biol 2016[May]; 17 (1 ): 111 PMID27224977 show ga
  • BACKGROUND: High-throughput sequencing enables unbiased profiling of microbial communities, universal pathogen detection, and host response to infectious diseases. However, computation times and algorithmic inaccuracies have hindered adoption. RESULTS: We present Taxonomer, an ultrafast, web-tool for comprehensive metagenomics data analysis and interactive results visualization. Taxonomer is unique in providing integrated nucleotide and protein-based classification and simultaneous host messenger RNA (mRNA) transcript profiling. Using real-world case-studies, we show that Taxonomer detects previously unrecognized infections and reveals antiviral host mRNA expression profiles. To facilitate data-sharing across geographic distances in outbreak settings, Taxonomer is publicly available through a web-based user interface. CONCLUSIONS: Taxonomer enables rapid, accurate, and interactive analyses of metagenomics data on personal computers and mobile devices.
  • |*Gene Expression Profiling [MESH]
  • |*Software [MESH]
  • |*Transcriptome [MESH]
  • |Algorithms [MESH]
  • |Bacteria/classification/genetics [MESH]
  • |Databases, Nucleic Acid [MESH]
  • |Fungi/classification/genetics [MESH]
  • |High-Throughput Nucleotide Sequencing [MESH]
  • |Host-Pathogen Interactions/*genetics [MESH]
  • |Metagenomics/*methods [MESH]
  • |User-Computer Interface [MESH]
  • |Viruses/classification/genetics [MESH]


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