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10.3390/cancers8050048 http://scihub22266oqcxt.onion/10.3390/cancers8050048 C4880865!4880865!27187476     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancers+(Basel) 2016 ; 8 (5): ä Nephropedia Template TP {{tp|p=27187476|t=2016. The Wnt Target Gene L1 in Colon Cancer Invasion and Metastasis |pdf=|usr=}}{{27187476}} gab.com Text The Wnt Target Gene L1 in Colon Cancer Invasion and Metastasis JO: Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27187476 #FOAvip The Wnt-?-catenin signaling pathway is highly conserved during evolution and determines normal tissue homeostasis. Hyperactivation of Wnt-?-catenin signaling is a characteristic feature of colorectal cancer (CRC) development. ?-catenin is a major transducer of the Wnt signal from the cytoplasm into the nucleus where it acts as a co-transcriptional activator of ?-catenin-TCF target genes. ?-catenin is also required for linking cadherin type cell-cell adhesion receptors to the cytoskeleton, and consequently Wnt-?-catenin signaling is an attractive system for investigating the role of adhesion-mediated signaling in both normal intestinal tissue homeostasis and CRC development. In this review, we summarize our studies on one Wnt-?-catenin target gene, L1, a member of the immunoglobulin-like cell adhesion transmembrane receptor family. We describe the mechanisms of L1-mediated signaling in CRC cells, its exclusive localization in invasive areas of CRC tissue, and its ability to increase cell motility and confer metastasis to the liver. We discuss the activation (by L1) of genes via an ezrin-NF-?B pathway and the induction of genes also found in the intestinal stem cell signature. By studying L1 (adhesion)-mediated signaling, we expect to learn about mechanisms regulating both normal intestinal homeostasis and CRC development. Twit Text FOAVip The Wnt Target Gene L1 in Colon Cancer Invasion and Metastasis ????Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27187476 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27187476 #FOAvip English Wikipedia <ref>{{Cite pmid|27187476}}</ref> The Wnt Target Gene L1 in Colon Cancer Invasion and Metastasis #MMPMID27187476 Haase G; Gavert N; Brabletz T; Ben-Ze?ev A Cancers (Basel) 2016[May]; 8 (5): ä PMID27187476show ga The Wnt-?-catenin signaling pathway is highly conserved during evolution and determines normal tissue homeostasis. Hyperactivation of Wnt-?-catenin signaling is a characteristic feature of colorectal cancer (CRC) development. ?-catenin is a major transducer of the Wnt signal from the cytoplasm into the nucleus where it acts as a co-transcriptional activator of ?-catenin-TCF target genes. ?-catenin is also required for linking cadherin type cell-cell adhesion receptors to the cytoskeleton, and consequently Wnt-?-catenin signaling is an attractive system for investigating the role of adhesion-mediated signaling in both normal intestinal tissue homeostasis and CRC development. In this review, we summarize our studies on one Wnt-?-catenin target gene, L1, a member of the immunoglobulin-like cell adhesion transmembrane receptor family. We describe the mechanisms of L1-mediated signaling in CRC cells, its exclusive localization in invasive areas of CRC tissue, and its ability to increase cell motility and confer metastasis to the liver. We discuss the activation (by L1) of genes via an ezrin-NF-?B pathway and the induction of genes also found in the intestinal stem cell signature. By studying L1 (adhesion)-mediated signaling, we expect to learn about mechanisms regulating both normal intestinal homeostasis and CRC development. äThe Wnt Target Gene L1 in Colon Cancer Invasion and Metastasis (epmc).pdf DeepDyve Pubget Overpricing