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10.3390/genes7050017 http://scihub22266oqcxt.onion/10.3390/genes7050017 C4880837!4880837!27136588     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+(Basel) 2016 ; 7 (5): ä Nephropedia Template TP {{tp|p=27136588|t=2016. Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients |pdf=|usr=}}{{27136588}} gab.com Text Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27136588 #FOAvip End-stage renal disease (ESRD) patients have a high mortality rate that exceeds that of non-ESRD population. The hemodialysis procedure induces neutrophil activation and elastase release, which might have a role in the inflammatory process and in the development of oxidative stress. The ELANE gene encodes the neutrophil elastase. We analyzed the effect of ELANE promoter region polymorphisms and its relation with the circulating levels of elastase, as well as several clinical, biochemical and inflammatory markers in 123 ESRD patients. We found two duplications in heterozygosity in the promoter region and a new polymorphism, the c.-801G>A. ESRD patients heterozygous for the c.-903T>G polymorphism had no changes in the circulating levels of elastase or other evaluated variables, and those homozygous for the c.-741G>A polymorphism showed significant effects on neutrophils count, as well as in neutrophils/lymphocytes ratio, which might be associated with an increased inflammatory process. Twit Text FOAVip Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27136588 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27136588 #FOAvip English Wikipedia <ref>{{Cite pmid|27136588}}</ref> Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients #MMPMID27136588 Fernandes R; Freitas B; Miranda V; Costa E; Santos-Silva A; Bronze-da-Rocha E Genes (Basel) 2016[May]; 7 (5): ä PMID27136588show ga End-stage renal disease (ESRD) patients have a high mortality rate that exceeds that of non-ESRD population. The hemodialysis procedure induces neutrophil activation and elastase release, which might have a role in the inflammatory process and in the development of oxidative stress. The ELANE gene encodes the neutrophil elastase. We analyzed the effect of ELANE promoter region polymorphisms and its relation with the circulating levels of elastase, as well as several clinical, biochemical and inflammatory markers in 123 ESRD patients. We found two duplications in heterozygosity in the promoter region and a new polymorphism, the c.-801G>A. ESRD patients heterozygous for the c.-903T>G polymorphism had no changes in the circulating levels of elastase or other evaluated variables, and those homozygous for the c.-741G>A polymorphism showed significant effects on neutrophils count, as well as in neutrophils/lymphocytes ratio, which might be associated with an increased inflammatory process. äPolymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic K(epmc).pdf DeepDyve Pubget Overpricing