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Adenocarcinoma of Mullerian origin: review of pathogenesis, molecular biology,
and emerging treatment paradigms
#MMPMID27231561
Cobb LP
; Gaillard S
; Wang Y
; Shih IeM
; Secord AA
Gynecol Oncol Res Pract
2015[]; 2
(?): 1
PMID27231561
show ga
Traditionally, epithelial ovarian, tubal, and peritoneal cancers have been viewed
as separate entities with disparate origins, pathogenesis, clinical features, and
outcomes. Additionally, previous classification systems for ovarian cancer have
proposed two primary histologic groups that encompass the standard histologic
subtypes. Recent data suggest that these groupings no longer accurately reflect
our knowledge surrounding these cancers. In this review, we propose that
epithelial ovarian, tubal, and peritoneal carcinomas represent a spectrum of
disease that originates in the Mullerian compartment. We will discuss the
incidence, classification, origin, molecular determinants, and pathologic
analysis of these cancers that support the conclusion they should be collectively
referred to as adenocarcinomas of Mullerian origin. As our understanding of the
molecular and pathologic profiling of adenocarcinomas of Mullerian origin
advances, we anticipate treatment paradigms will shift towards genomic driven
therapeutic interventions.