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2016 ; 92
(1
): 20-8
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Novel concept of iSALT (inducible skin-associated lymphoid tissue) in the
elicitation of allergic contact dermatitis
#MMPMID26755397
Honda T
; Kabashima K
Proc Jpn Acad Ser B Phys Biol Sci
2016[]; 92
(1
): 20-8
PMID26755397
show ga
Allergic contact dermatitis (ACD) is one of the most common inflammatory skin
diseases, which is classified as a delayed-type hypersensitivity immune response.
The development of ACD is divided into two phases: sensitization and elicitation.
In the sensitization phase, antigen-specific effector T cells are induced in the
draining lymph nodes by antigen-captured cutaneous dendritic cells (DCs) that
migrate from the skin. In the elicitation phase, the effector T cells are
activated in the skin by antigen-captured cutaneous DCs and produce various
chemical mediators, which create antigen-specific inflammation. In this review,
we discuss the recent advancements in the immunological mechanisms of ACD,
focusing on the mechanisms in the elicitation phase. The observations of
elicitation of CHS lead to the emerging novel concept of iSALT (inducible
skin-associated lymphoid tissue).