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2016 ; 92
(1
): 1-19
Nephropedia Template TP
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English Wikipedia
From migration to settlement: the pathways, migration modes and dynamics of
neurons in the developing brain
#MMPMID26755396
Hatanaka Y
; Zhu Y
; Torigoe M
; Kita Y
; Murakami F
Proc Jpn Acad Ser B Phys Biol Sci
2016[]; 92
(1
): 1-19
PMID26755396
show ga
Neuronal migration is crucial for the construction of the nervous system. To
reach their correct destination, migrating neurons choose pathways using physical
substrates and chemical cues of either diffusible or non-diffusible nature.
Migrating neurons extend a leading and a trailing process. The leading process,
which extends in the direction of migration, determines navigation, in particular
when a neuron changes its direction of migration. While most neurons simply
migrate radially, certain neurons switch their mode of migration between radial
and tangential, with the latter allowing migration to destinations far from the
neurons' site of generation. Consequently, neurons with distinct origins are
intermingled, which results in intricate neuronal architectures and
connectivities and provides an important basis for higher brain function. The
trailing process, in contrast, contributes to the late stage of development by
turning into the axon, thus contributing to the formation of neuronal circuits.