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10.1146/annurev-physiol-021113-170305 http://scihub22266oqcxt.onion/10.1146/annurev-physiol-021113-170305 C4880020!4880020!24274740     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Physiol 2014 ; 76 (ä): 301-31 Nephropedia Template TP {{tp|p=24274740|t=2014. Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms* |pdf=|usr=}}{{24274740}} gab.com Text Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms* JO: Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24274740 #FOAvip Vesicle exocytosis releases content to mediate many biological events, including synaptic transmission essential for brain functions. Following exocytosis, endocytosis is initiated to retrieve exocytosed vesicles within seconds to minutes. Decades of studies in secretory cells reveal three exocytosis modes coupled to three endocytosis modes: (a) full-collapse fusion, in which vesicles collapse into the plasma membrane, followed by classical endocytosis involving membrane invagination and vesicle reformation; (b) kiss-and-run, in which the fusion pore opens and closes; and (c) compound exocytosis, which involves exocytosis of giant vesicles formed via vesicle-vesicle fusion, followed by bulk endocytosis that retrieves giant vesicles. Here we review these exo- and endocytosis modes and their roles in regulating quantal size and synaptic strength, generating synaptic plasticity, maintaining exocytosis, and clearing release sites for vesicle replenishment. Furthermore, we highlight recent progress in understanding how vesicle endocytosis is initiated and is thus coupled to exocytosis. The emerging model is that calcium influx via voltage-dependent calcium channels at the calcium microdomain triggers endocytosis and controls endocytosis rate; calmodulin and synaptotagmin are the calcium sensors; and the exocytosis machinery, including SNARE proteins (synaptobrevin, SNAP25, and syntaxin), is needed to coinitiate endocytosis, likely to control the amount of endocytosis. Twit Text FOAVip Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms* ????Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24274740 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24274740 #FOAvip English Wikipedia <ref>{{Cite pmid|24274740}}</ref> Exocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms* #MMPMID24274740 Wu LG; Hamid E; Shin W; Chiang HC Annu Rev Physiol 2014[]; 76 (ä): 301-31 PMID24274740show ga Vesicle exocytosis releases content to mediate many biological events, including synaptic transmission essential for brain functions. Following exocytosis, endocytosis is initiated to retrieve exocytosed vesicles within seconds to minutes. Decades of studies in secretory cells reveal three exocytosis modes coupled to three endocytosis modes: (a) full-collapse fusion, in which vesicles collapse into the plasma membrane, followed by classical endocytosis involving membrane invagination and vesicle reformation; (b) kiss-and-run, in which the fusion pore opens and closes; and (c) compound exocytosis, which involves exocytosis of giant vesicles formed via vesicle-vesicle fusion, followed by bulk endocytosis that retrieves giant vesicles. Here we review these exo- and endocytosis modes and their roles in regulating quantal size and synaptic strength, generating synaptic plasticity, maintaining exocytosis, and clearing release sites for vesicle replenishment. Furthermore, we highlight recent progress in understanding how vesicle endocytosis is initiated and is thus coupled to exocytosis. The emerging model is that calcium influx via voltage-dependent calcium channels at the calcium microdomain triggers endocytosis and controls endocytosis rate; calmodulin and synaptotagmin are the calcium sensors; and the exocytosis machinery, including SNARE proteins (synaptobrevin, SNAP25, and syntaxin), is needed to coinitiate endocytosis, likely to control the amount of endocytosis. äExocytosis and Endocytosis: Modes, Functions, and Coupling Mechanisms*(epmc).pdf DeepDyve Pubget Overpricing