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10.1016/j.anaerobe.2016.02.011

http://scihub22266oqcxt.onion/10.1016/j.anaerobe.2016.02.011
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C4879870!4879870!26946361
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suck abstract from ncbi


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pmid26946361      Anaerobe 2016 ; 39 (ä): 51-3
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  • Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection #MMPMID26946361
  • Kelly ML; Ng YK; Cartman ST; Collery MM; Cockayne A; Minton NP
  • Anaerobe 2016[Jun]; 39 (ä): 51-3 PMID26946361show ga
  • Comparative analysis of the Clostridium difficile BI/NAP1/027 strain R20291 and ClosTron-derived ermB mutants in the hamster infection model are compromised by the clindamycin susceptibility of the parent. Mutants can appear more virulent. We have rectified this anomaly by genome engineering. The variant created (CRG20291) represents an ideal control strain for virulence assays of ClosTron mutants.
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